新医学2025，Vol.56Issue(5)：528-536,9.DOI:10.12464/j.issn.0253-9802.2024-0500
GPR120的功能特性及其抗动脉粥样硬化机制研究
The functional characteristics of GPR120 and its mechanism in preventing atherosclerosis
摘要
Abstract
Free fatty acids are important substances for regulating energy metabolism in the body and mainly exert their functions by binding to G protein-coupled receptors(GPRs)on the cell membrane.GPR120 is the receptor for medium and long-chain free fatty acids in mammals.Studies have found that the activation of GPR120 on endothelial cells,vascular smooth muscle cells,and monocytes/macrophages can reduce monocyte adhesion,promote cholesterol efflux from foam cells,regulate the migration and differentiation of macrophages,and exert anti-inflammatory and antioxidant functions,potentially resisting atherosclerosis.This article reviews the molecular structure,tissue distribution,ligand types,signal transduction pathways of GPR120,and its research progress in anti-atherosclerotic diseases,aiming to reveal the molecular mechanism of GPR120 in resisting atherosclerosis and its potential value as a therapeutic target.关键词
G蛋白偶联受体120/动脉粥样硬化/巨噬细胞/炎症/胆固醇逆转运/心血管疾病Key words
G protein-coupled receptor 120/Atherosclerosis/Macrophage/Inflammation/Reverse cholesterol transport/Cardiovascular disease引用本文复制引用
肖佳海,陈耿基,张鹏飞,吴天羽,陈晓佳,张志珍..GPR120的功能特性及其抗动脉粥样硬化机制研究[J].新医学,2025,56(5):528-536,9.基金项目
广东省基础与应用基础研究基金自然科学基金(2020A1515010224) （2020A1515010224）
