新医学2025，Vol.56Issue(5)：537-542,6.DOI:10.12464/j.issn.0253-9802.2024-0014
靶向成纤维细胞激活蛋白新型显像剂的研究进展
Advances in novel imaging agents targeting fibroblast activation proteins
摘要
Abstract
Based on the high target-to-background ratio(TBR),new imaging agents targeting fibroblast activation protein(FAP)have shown better imaging effects in a variety of tumors.In recent years,with in-depth research,FAP inhibitor(FAPI)has shown great application prospects in tumor imaging and treatment.It can be used as a supplement to the mainstream metabolic imaging agent 18F-labeled fluorodeoxyglucose(18F-FDG),which provides the possibility of more efficient combination of tumor metabolism and tumor stroma visualization in the future.It is helpful to guide clinical diagnosis and treatment more accurately.This article mainly reviews the application of new FAP imaging agents in various tumors,compares them with existing radiological diagnostic methods,and summarizes the clinical application progress and future potential of tracers specifically targeting FAPI in tumors and non-specific tissues.关键词
成纤维细胞激活蛋白/放射性同位素/靶向制剂/肿瘤Key words
Fibroblast activation protein/Radioisotopes/Targeting preparation/Cancer引用本文复制引用
王宁,石怡珍..靶向成纤维细胞激活蛋白新型显像剂的研究进展[J].新医学,2025,56(5):537-542,6.基金项目
上海市分子影像学重点实验室一般项目(KFKT-2023-33) （KFKT-2023-33）
