中国医疗设备2025，Vol.40Issue(5)：24-33,41,11.DOI:10.3969/j.issn.1674-1633.20241874
纳米技术在组织工程与再生医学中的全球研究趋势与热点分析
Global Research Trends and Hotspot Analysis of Nanotechnology in Tissue Engineering and Regenerative Medicine
摘要
Abstract
Objective To systematically analyze the research literature on nanotechnology in the field of tissue engineering and regenerative medicine to reveal global research trends and hotspots in these areas,providing valuable reference information for researchers.Methods The Web of Science database was used as the data source,with the keyword combinations"nano""nanotechnology""nanomaterials"and"tissue engineering""regenerative medicine".A total of 4499 relevant papers published between 2010 and 2024 were retrieved.Data preprocessing and BERTopic topic modeling techniques were applied to perform topic clustering and analysis on the titles and abstracts of the papers.Results From 2010 to 2022,the number of papers published on nanotechnology in tissue engineering and regenerative medicine significantly increased.However,there were fluctuations in the annual publication volume,and since 2022,the number of papers published decreased.This study successfully identified 9 major research directions,including application of nanocomposite scaffold materials in bone tissue engineering;application of electrospinning technology in skin regeneration;application of nanotechnology in hydrogel materials;application of titanium and its oxides in tissue engineering;application of bacterial cellulose and chitosan in tissue engineering;application of nanomaterials in drug delivery;application of nanotechnology in cardiac tissue engineering;application of silk protein nanomaterials in tissue engineering;application of collagen-based scaffold materials in tendon and ligament repair.Conclusion Overall,nanotechnology has a broad research scope in tissue engineering and regenerative medicine,with most studies focusing on the optimization and functionalization of biomaterials.These studies have made significant progress in clinical fields such as orthopedics,dermatology,and cardiovascular surgery.In the future,multifunctional materials,personalized materials,and smart materials are expected to become the key research focus in this field.关键词
纳米技术/组织工程与再生医学/纳米材料/电纺技术/主题建模/BERTopic/热点分析Key words
nanotechnology/tissue engineering and regenerative medicine/nanometer material/electrospinning technology/topic modeling/BERTopic/hotspot analysis分类
基础医学引用本文复制引用
王建波,欧阳昭连..纳米技术在组织工程与再生医学中的全球研究趋势与热点分析[J].中国医疗设备,2025,40(5):24-33,41,11.基金项目
中国医学科学院医学与健康科技创新工程"医学知识管理与智能化知识服务关键技术研究"(2021-I2M-1-056) （2021-I2M-1-056）
国家自然科学基金(L1924064) （L1924064）
深圳市卫生健康发展研究和数据管理中心"组织工程与再生医学专题报告项目"(sz20240119). （sz20240119）
