医疗卫生装备2025，Vol.46Issue(5)：54-59,6.DOI:10.19745/j.1003-8868.2025087
DCE-MRI定量参数对非小细胞肺癌脑转移瘤病理类型的鉴别诊断价值
Value of DCE-MRI quantitative parameters in differential diagnosis of brain metastases from non-small cell lung cancer
摘要
Abstract
Objective To evaluate the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in differentiating histopathological types of brain metastases from non-small cell lung cancer(NSCLC).Methods Sixty-eight patients with brain metastases confirmed by pathology were collected,including 47 lung adenocarcinoma patients divided into a lung adenocarcinoma group and 21 lung squamous cell carcinoma patients into a lung squamous cell carcinoma group.The two groups were compared in terms of the DCE-MRI derived parameters including volume transfer constant(Ktrans),extra vascular extracellular volume fraction(Ve)and plasma volume fraction(Vp);ROC curves were used to assess the diagnostic efficacy of different quantitative parameters for the pathologic types of brain metastases from lung adenocarcinoma group or lung squamous cell carcinoma.SPSS 22.0 software was used for statistical analysis.Results The lung adenocarcinoma group had the values of Ktrans,Ve,Vp and Ve+Vp higher than those of the lung squamous cell carcinoma group,with the differences being statistically significant(all P＜0.05).ROC curve analysis results showed that Ktrans,Vp and Ve had high differential diagnosis values for the pathologic types of brain metastases from lung adenocarcinoma group or lung squamous cell carcinoma,with the AUC being 1.000,0.998 and 0.875,the optimal Youden index being 0.183 min-1,0.039 and 0.270,the sensitivity being 100.00％,100.00％and 80.56％and the specificity being 100.00％,97.06％and 80.88％,respectively.Conclusion The quantitative parameters of DCE-MRI gain advantages in the differential diagnosis of NSCLC brain metastases,and provide references for the diagnosis and treatment of brain metastases of lung cancer.[Chinese Medical Equipment Journal,2025,46(5):54-59]关键词
非小细胞肺癌/脑转移瘤/动态对比增强磁共振成像/定量参数/病理类型Key words
non-small cell lung cancer/brain metastases/dynamic contrast-enhanced magnetic resonance imaging/quantitative parameter/pathological type分类
基础医学引用本文复制引用
梁瑞鹏,李永隆,王昊天,苏丹,张秀富,周军..DCE-MRI定量参数对非小细胞肺癌脑转移瘤病理类型的鉴别诊断价值[J].医疗卫生装备,2025,46(5):54-59,6.基金项目
重庆市科卫联合青年项目基金(2024QNXM042) （2024QNXM042）
重庆市教育委员会科学技术研究计划青年项目基金(KJQN202400112) （KJQN202400112）
重庆大学附属江津医院院级项目基金(2023yjky005) （2023yjky005）
重庆大学附属江津医院院级培育项目基金(2024LCXM003) （2024LCXM003）
