云南民族大学学报（自然科学版）2025，Vol.34Issue(3)：284-293,10.DOI:10.3969/j.issn.1672-8513.2025.03.005
肠道菌群介导的脑肠轴通路调控炎症性肠病
Regulation of inflammatory bowel disease via the gut microbiota-mediated brain-gut axis pathway
摘要
Abstract
Inflammatory bowel disease(IBD)is a prevalent functional gastrointestinal disorder in clinical settings.Current research on the pathogenesis of IBD mainly focuses on genetic susceptibility,psychosocial stress,visceral hypersensitivity,dysregulation of the brain-gut axis,dysbiosis of the gut microbiota,and abnormalities in the intestinal mucosal immune system.However,these pathogenic mechanisms are not discrete entities.As research advances,the aberrant regulation of the brain-gut axis is increasingly recognized.This article delves into the correlation between gut microbiota dysbiosis and dysregulation of the brain-gut axis in IBD,offering compelling evidence for the interconnected pathogenic mechanisms involving the brain-gut axis and gut microbiota dysfunction in IBD.关键词
炎症性肠病/肠道菌群/脑肠轴Key words
inflammatory bowel disease/gut microbiota/brain-gut axis分类
医药卫生引用本文复制引用
杨灿娇,王梅,杨恒俐,张建英,秦冬冬,何红平,李艳平..肠道菌群介导的脑肠轴通路调控炎症性肠病[J].云南民族大学学报（自然科学版）,2025,34(3):284-293,10.基金项目
国家自然科学基金(81960777) （81960777）
云南省应用基础研究计划项目中医联合专项重点项目(202101AZ070001-326) （202101AZ070001-326）
云南省科学技术厅中医联合面上项目(202001AZ070001-029). （202001AZ070001-029）
