针刺研究2025，Vol.50Issue(5)：538-552,15.DOI:10.13702/j.1000-0607.20250346
针刺效应与神经免疫调控——"治病求本"的突破
Acupuncture effects and neuro-immune regulation:a breakthrough in"treating diseases at the root"
摘要
Abstract
The holistic philosophy of traditional Chinese medicine(TCM)embodied in acupuncture therapy has gained novel insights within the neuroimmune regulatory framework.Its mechanistic framework encompasses 3 pivotal dimensions:1)Acupuncture stimulation at acupoints transduces mechanical signals into neuroelectrical and biochemical signals,initiating localized immunomodulatory microenvironment remodeling;2)The autonomic nervous system orchestrates systemic and organ-specific immune homeostasis through vagus nerve-mediated anti-inflammatory effects and sympathetic nerve-mediated bidirectional regulatory dynamics;3)The enteric nervous system facilitates barrier restoration via neuropeptide-microbiota crosstalk,establishing bidirectional gut-brain axis immune communication.Emerging bioelectronic devices based on somatosensory-autonomic reflex circuits are driving the evolution of acupuncture from empirical practice to precision neuromodulation.Future research should integrate multi-omics profiling and artificial intelligence algorithms to construct a comprehensive"mechanical stimulation-neural coding-immune response"mapping paradigm.This will operationalize TCM's core principle of"treating the root of disease"into targeted neuromodulation strategies against inflammatory and immune-related disorders through defined neural circuit interventions.关键词
针刺/神经免疫/躯体感觉/自主神经Key words
Acupuncture/Neuro-immune/Somatosensory/Autonomic nerve引用本文复制引用
田嘉禾,万红叶,柳申滨..针刺效应与神经免疫调控——"治病求本"的突破[J].针刺研究,2025,50(5):538-552,15.基金项目
中国中医科学院科技创新工程项目(No.CI2021B011) （No.CI2021B011）
