中国病理生理杂志2025，Vol.41Issue(5)：1006-1013,8.DOI:10.3969/j.issn.1000-4718.2025.00.012
驱动蛋白超家族参与病理性疼痛机制的研究进展
Progress in mechanism of kinesin superfamily proteins involved in patho-logic pain
摘要
Abstract
Kinesin superfamily proteins(KIFs)are motor proteins that travel along microtubules and facilitate the transport of small biological molecules within cells.Various kinesin proteins are present in the dorsal root ganglion and spinal dorsal horn,where they modulate the excitability and sensitivity of sensory neurons,contributing to the occurrence and maintenance of pathological pain.Therefore,they represent potential therapeutic targets for the treatment of pathologi-cal pain.This review provides a comprehensive overview of the recent advancements in understanding the peripheral and central mechanisms of kinesins in the context of pathological pain,offering valuable insights for the potential development of analgesic medications targeting kinesin.关键词
驱动蛋白/病理性疼痛/脊髓/背根神经节Key words
kinesin/pathologic pain/spinal cord/dorsal root ganglion分类
医药卫生引用本文复制引用
陈书杰,徐陶,金寰,曾俊伟,刘晓红..驱动蛋白超家族参与病理性疼痛机制的研究进展[J].中国病理生理杂志,2025,41(5):1006-1013,8.基金项目
国家自然科学基金资助项目(No.31860291) （No.31860291）
贵州省教育厅创新群体重大研究项目(黔教合KY字[2018]025号) （黔教合KY字[2018]025号）
