局解手术学杂志2025，Vol.34Issue(5)：395-400,6.DOI:10.11659/jjssx.09E024138
基于泛癌分析的线粒体MT-ND家族基因在癌症中的预后价值
Prognostic value of mitochondrial MT-ND family genes in cancer based on a pan-cancer analysis
摘要
Abstract
Objective To explore the abnormal expression of the MT-ND family in pan-cancers and its prognostic value.Methods Transcriptome expression and clinical data of 33 cancers were downloaded from the TCGA database,thereby analyzing the expression differences of the MT-ND family in tissuesof different types of cancers and normal tissues.The prognostic role of the MT-ND family in pan-cancers was explored by univariate Cox regression analysis and Kaplan-Meier survival analysis.Results The expression of the MT-ND family was upregulated in the kidney chromophobe,acute myeloid leukemia and thymoma,and downregulated in the remaining tumors.The expression of the MT-ND family was associated with the overall survival rate of different types of cancers.In addition,the MT-ND family were significantly correlated with the immune invasion subtypes,and were correlated with stromal cell invasion and tumor cell stemness to varying degrees.The expression of MT-ND4 was downregulated in brain lower grade glioma,which was a protective factor for prognosis;while the expression of MT-ND4 in thymoma was upregulated,which was a risk factor for prognosis.Conclusion Pan-cancer analysis has confirmed that the MT-ND family can predict the tumor prognosis,which provides new ideas and strategies for the precision treatment and prognostic management of cancer.关键词
MT-ND家族/泛癌/TCGA/预后因素/肿瘤微环境Key words
MT-ND family/pan-cancer/TCGA/prognostic factor/tumor microenvironment分类
生物学引用本文复制引用
张海佳,陈思,常程,高凯月,王立杰..基于泛癌分析的线粒体MT-ND家族基因在癌症中的预后价值[J].局解手术学杂志,2025,34(5):395-400,6.基金项目
吉林省科技厅资助项目(20240304063SF) （20240304063SF）
