局解手术学杂志2025，Vol.34Issue(5)：421-424,4.DOI:10.11659/jjssx.06E024125
乳腺癌组织中NUDT5表达及其与超声征象和临床病理特征的相关性
Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological charac-teristics
荣鹿 1周敏 1于鲁欣 1吕娟 1万静 1张倩2
作者信息
- 1. 新疆维吾尔自治区人民医院超声科,新疆 乌鲁木齐 830002
- 2. 新疆维吾尔自治区人民医院乳甲外科,新疆 乌鲁木齐 830002
- 折叠
摘要
Abstract
Objective To explore the expression of Nudix hydrolase 5(NUDT5)protein in breast cancer tissues and its correlation with ultrasound signs and clinicopathological characteristics.Methods A total of 108 patients with breast cancer admitted to our hospital from October 2019 to April 2022 were selected as the research objects.Ultrasound examination was performed before operation to observe the ultrasound signs of patients.Immunohistochemical method was used to detect the expressions of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER-2)in breast cancer tissues,and the expression levels of NUDT5 protein in breast cancer tissues and adjacent tissues,and the relationships of NUDT5 protein expression with ultrasound signs and clinicopathological characteristics of patients were analyzed.Results Among 108 patients,there were 62 cases with ER positive,60 cases with PR positive,and 28 cases with HER-2 positive.The positive expression rate of NUDT5 protein in breast cancer tissues was higher than that in adjacent tissues(P<0.05).The positive expression rate of NUDT5 protein was higher in breast cancer tissues with microcalcification,blood flow imaging grade(grade 2 to 3)and lymph node metastasis(P<0.05).The positive expression of NUDT5 protein was correlated with histological grade,ER and HER-2(P<0.05).The expression of NUDT5 protein in breast cancer tissue was positively correlated with ER negative and HER-2 positive(rs=0.463,0.398,P<0.05).Conclusion The positive expression rate of NUDT5 protein in breast cancer tissues is higher than that in adjacent tissues,and its expression has a certain correlation with microcalcification,blood flow imaging grade(grade 2 to 3),lymph node metastasis in ultrasound signs and histological grade,ER,and HER-2 in clinicopathological characteristics.关键词
Nudix结构水解酶5/乳腺癌/超声征象/相关性Key words
Nudix hydrolase 5/breast cancer/ultrasound signs/correlation分类
医药卫生引用本文复制引用
荣鹿,周敏,于鲁欣,吕娟,万静,张倩..乳腺癌组织中NUDT5表达及其与超声征象和临床病理特征的相关性[J].局解手术学杂志,2025,34(5):421-424,4.
