局解手术学杂志2025，Vol.34Issue(5)：452-457,6.DOI:10.11659/jjssx.10E024101
铜死亡在卵巢癌中的研究进展
Research progress of cuproptosis in ovarian cancer
摘要
Abstract
Ovarian cancer,as one of the three major malignant tumors in gynecology,has a relatively high mortality rate.Traditional adjuvant chemotherapy has failed to significantly improve the survival rate of patients in the advanced stage due to its high drug resistance.Therefore,new treatment methods are urgently needed to improve the survival rate of patients.Cuproposis is a newly proposed form of cell death,which is caused by the accumulation of lipoylated protein and the loss of Fe-S cluster protein by copper overload,and it is expected to be a new treatment method for ovarian cancer to improve the prognosis of patients.Previous studies have shown that cuproptosis related genes are differentially expressed in ovarian cancer,which can guide personalized immunotherapy and participate in chemotherapy resistance.This article will review the correlation between the mechanisms related to cuproptosis and ovarian cancer,and explore whether it can provide new ideas for the treatment of ovarian cancer in the future.关键词
卵巢癌/铜死亡/铜代谢/铜离子转运体/免疫治疗/铜离子载体Key words
ovarian cancer/cuproptosis/copper metabolism/copper transporter/immunotherapy/copper ionophore分类
医药卫生引用本文复制引用
蔡苗苗,范雅丹,邓青春..铜死亡在卵巢癌中的研究进展[J].局解手术学杂志,2025,34(5):452-457,6.基金项目
国家自然科学基金资助项目(82360595) （82360595）
