中国康复理论与实践2025，Vol.31Issue(5)：607-612,6.DOI:10.3969/j.issn.1006-9771.2025.05.014
时间间隔对持续性θ爆发刺激预调控间歇性θ爆发刺激诱导运动皮质可塑性的影响
Effect of time intervals of priming continuous theta burst stimulationon on cortical plasticity induced by intermit-tent theta burst stimulation
摘要
Abstract
Objective To investigate the effect of continuous theta burst stimulation-intermittent theta burst stimulation(cTBS-iT-BS)priming protocols with different time intervals on the plasticity of primary motor cortex(M1). Methods A total of 39 healthy young adults were recruited from Changzhou De'an Hospital from March to August,2024.Participants received cTBS-iTBS priming protocols with intervals of 5 minutes,10 minutes and 15 minutes using a randomized crossover design.Motor-evoked potential(MEP)amplitudes in M1 were recorded at baseline(before intervention)and 0 minute,10 minutes,20 minutes and 30 minutes after intervention. Results The main effects of stimulation protocol(F=19.761,P<0.001)and measurement time(F=10.224,P<0.001)were significant.At each time point after intervention,the MEP amplitude was significantly higher under the 10-minute interval than under the 5-minute and 15-minute intervals(t>3.010,P<0.05). Conclusion The 10-minute interval of cTBS-iTBS is more effective on M1 plasticity.关键词
θ爆发刺激/可塑性/运动诱发电位/双向突触可塑性理论Key words
theta burst stimulation/plasticity/motor-evoked potential/Bienenstock-Cooper-Munro theory分类
医药卫生引用本文复制引用
耿阿燕,王庆雷,沈俊帆,朱仕哲,季盼盼,王彤,郭川..时间间隔对持续性θ爆发刺激预调控间歇性θ爆发刺激诱导运动皮质可塑性的影响[J].中国康复理论与实践,2025,31(5):607-612,6.基金项目
国家自然科学基金青年项目(No.82302882) Supported by National Natural Science Foundation of China(Youth)(No.82302882) （No.82302882）
