中国临床药理学杂志2025，Vol.41Issue(6)：751-754,4.DOI:10.13699/j.cnki.1001-6821.2025.06.001
气肿性肾盂肾炎患者的临床特征及菌株耐药性分析
Clinical characteristics and drug resistance of strain analysis of patients with emphysematous pyelonephritis
摘要
Abstract
Objective To analyze the clinical characteristics of patients infected with emphysematous pyelonephritis(EPN)and the drug resistance of the strains.To enhance the understanding of EPN,provide a basis for the selection of antibacterial drugs in clinical practice.Methods Evaluated 15 EPN patients'clinical characteristics and outcome,analysis of pathogenic bacteria and drug resistance.Results Among the 15 EPN patients,66.67％(10 cases/15 cases)patients were cured,13.33％(2 cases/15 cases)patients died,and 20.00％(3 cases/15 cases)patients were adverse.Fluid cultures identified 12 strains of pathogenic bacteria,with Escherichia coli being the most prevalent(66.67％,8 cases/12 cases),followed by Klebsiella pneumoniae(25.00％,3 cases/12 cases),and Pseudomonas aeruginosa was the least common(8.33％,1 cases/12 cases),75.00％(9 cases/12 cases)of the strains were multi-drug resistant.The drug sensitivity test results showed that amikacin,cefotetan,and cefoperazone sulbactam were 100.00％sensitive antibiotics;the sensitivity rates of meropenem,imipenem,and ertapenem were 91.67％.Conclusion Patients with EPN have high mortality and poor prognosis.Escherichia coli was the most common pathogenic bacteria,followed by Klebsiella pneumoniae,and the proportion of multi-drug resistant strains was high.We recommend the use of over 90％of the pathogen-sensitive drugs with susceptibility about 90％identified in this study.关键词
气肿性肾盂肾炎/体液培养/耐药性分析/临床特征Key words
emphysematous pyelonephritis/body fluid cultures/drug sensitivity analysis/clinical features分类
药学引用本文复制引用
孙程程,张嘉恩,刘义,熊辉,马义祥..气肿性肾盂肾炎患者的临床特征及菌株耐药性分析[J].中国临床药理学杂志,2025,41(6):751-754,4.基金项目
中央高水平医院临床科研业务费资助(北京大学第一医院科研种子基金项目)(2024SF102) （北京大学第一医院科研种子基金项目）
