中国输血杂志2025，Vol.38Issue(5)：615-620,636,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.05.004
CD36抗原表达大规模筛查及阴性供者结构与供能分析
Mass screening for CD36 antigen expression and analysis of negative donor structure and supply capacity
摘要
Abstract
Objective To establish a database of CD36 antigen-negative donors through large-scale screening of aphere-sis platelet donors in Shenzhen for CD36 deficiency subtypes and blood group distribution,and to assess clinical demand and blood supply capacity through a retrospective analysis of the apheresis platelet donation volumes from 2019 to 2023.Meth-ods Flow cytometry with fluorescent CD36 monoclonal antibodies was employed to screen platelet/monocyte CD36 deficien-cy(Type Ⅰ and Ⅱ),and statistical analyses were conducted using SPSS software(version 27.0).Results Among 11 603 apheresis platelet donors,248(2.14％)exhibited CD36 deficiency,comprising 51 type Ⅰ(0.43％,51/11,603)and 197 type Ⅱ(1.70％,197/11,603)cases,with significant difference(P<0.001).CD36 deficient platelets were mainly dis-tributed in blood group B(2.28％,902.3/39 602.1)and AB(2.14,269/12 544.5),significantly exceeding those in blood group A(1.43％,667/46 508.4)and O(1.64％,1 000/60 965.6)(P<0.001).The proportion of donors with 10-100 U from CD36 deficient donors was the highest(51％,1 446.4/2 838.3).Conclusion Sustained screening for CD36-deficient donors is recommended to meet the clinical transfusion needs for immunized patients and those requiring an-tigen-negative products.Regional resource-sharing mechanisms should be optimized to maximize utilization of CD36-defi-cient platelet inventories.关键词
单采血小板/CD36抗原表达/CD36缺失/流式细胞术/血型分布Key words
apheresis platelet/CD36 antigen expression/CD36 deficiency/flow cytometry/blood group distribution分类
医药卫生引用本文复制引用
徐筠娉,熊镗睿,杨帆,夏文霞,李喜淼,车华涛,李智磊..CD36抗原表达大规模筛查及阴性供者结构与供能分析[J].中国输血杂志,2025,38(5):615-620,636,7.基金项目
广东省医学科研基金(A2023189) （A2023189）
深圳市医疗卫生三名工程项目(No.SZSM202311032) （No.SZSM202311032）
深圳市重点医学学科(SZXK070) （SZXK070）
南山区卫健系统重大项目区校合作优秀青年基金项目(NSZD2023062). （NSZD2023062）
