中国输血杂志2025，Vol.38Issue(5)：699-703,5.DOI:10.13303/j.cjbt.issn.1004-549x.2025.05.016
较低红细胞比容患者血浆置换治疗安全性评价
Safety evaluation of therapeutic plasma exchange in patients with lower hematocrit levels
李营 1杨元铭 1孟子凡 1刘政 1王海燕1
作者信息
- 1. 青岛大学附属医院 输血科,山东 青岛 266003
- 折叠
摘要
Abstract
Objective To retrospectively assess whether a lower hematocrit level(between 18%and 20%)had any im-pact on the safety of patients undergoing therapeutic plasma exchange(TPE),and to further determine the threshold for red blood cell supplementation prior to TPE.Methods Clinical data from 181 adult patients who underwent TPE treatment at the Department of Blood Transfusion of our hospital from March 2023 to July 2024 were collected.The patients were divided into a study group of 44 patients(Hct≥18%and<20%)and a control group of 137 patients(Hct≥20%).In two groups,blood volume-related safety indicators including respiration rate,heart rate,systolic blood pressure,and blood oxy-gen saturation levels before and after TPE were compared using t-test.Between-group differences in the grading of adverse reactions such as allergies and hypotension were analyzed using chi-square test.Results A total of 659 TPE treatments were performed on 181 patients,with 169 TPE treatments on 44 patients in the study group(Hct≥18%and<20%)and 490 TPE treatments on 137 patients in the control group(Hct≥20%).There were no statistically significant differences in age,gender,BMI category,and the presence of cardiac insufficiency between the two groups.In the study group,there were no statistically significant differences in safety indicators such as respiration rate,heart rate,systolic blood pressure,and blood oxygen saturation level before and after TPE.In the control group,there were no statistically significant differ-ences in heart rate and systolic blood pressure before and after TPE,but there were statistically significant differences in res-piration rate and blood oxygen saturation level(P<0.05).There were no statistically significant differences in the grading of adverse reactions such as allergic reactions and hypotension between the two groups.Conclusion For adult patients with stable conditions,maintaining a lower hematocrit level(Hct≥18%and<20%)during TPE is relatively safe.It is feasible to lower the TPE red blood cell supplementation threshold to 18%≤Hct<20%,which may save blood resources while poten-tially benefit patients by avoiding unnecessary red blood cell transfusion.关键词
治疗性血浆置换/红细胞比容/安全性评价Key words
therapeutic plasma exchange(TPE)/hematocrit(Hct)/safety evaluation分类
医药卫生引用本文复制引用
李营,杨元铭,孟子凡,刘政,王海燕..较低红细胞比容患者血浆置换治疗安全性评价[J].中国输血杂志,2025,38(5):699-703,5.
