中国实用儿科杂志2025，Vol.40Issue(4)：271-283,13.DOI:10.19538/j.ek2025040602
三氧化二砷在儿童实体肿瘤临床应用中国专家共识
Chinese expert consensus on the clinical application of arsenic trioxide in pediatric solid tumors
摘要
Abstract
Arsenic trioxide(ATO),a traditional Chinese medicine with a longstanding history,is renowned for its efficacy in the treatment of acute promyelocytic leukemia(APL).Recently,more and more studies have demonstrated that ATO exhibits anti-tumor effects across a variety of malignancies,and it also showed some effects in the clinical treatment of pediatric tumors,which deserves further study.The lack of established guidelines and consensus regarding its clinical application in pediatric solid tumors has prompted the Specialty Committee of Pediatric Oncology of the Chinese Anti-Cancer Association and the Specialty Committee of Pediatric Oncology of Guangdong Anti-Cancer Association to organize domestic experts to make literature review and analysis and summary regarding the history of ATO,its anti-tumor mechanisms,its clinical application,and its pharmacokinetics.A full discussion was carried out concerning the indications,administration methods and the management of adverse reactions associated with ATO use in pediatric solid tumors,and reasonable suggestions were put forward based on evidence-based medical evidence and clinical experience,aiming to provide clinicians with evidence for the rational use of ATO in order to better improve the prognosis of pediatric patients with tumors and offer valuable references for pharmaceutical management departments.关键词
三氧化二砷/肿瘤/儿童/临床应用/共识Key words
arsenic trioxide/tumor/pediatric/clinical application/consensus分类
临床医学引用本文复制引用
中国抗癌协会小儿肿瘤专业委员会,广东省抗癌协会小儿肿瘤专业委员会,《中国实用儿科杂志》编辑委员会,黎阳,罗学群..三氧化二砷在儿童实体肿瘤临床应用中国专家共识[J].中国实用儿科杂志,2025,40(4):271-283,13.基金项目
广州市卫生健康委特色技术项目(2023P-TS39) （2023P-TS39）
中山大学孙逸仙纪念医院逸仙医工融合培育专项(YXYGRH202203) （YXYGRH202203）
浙江省领雁计划项目(2024C03181) （2024C03181）
