中国实用儿科杂志2025，Vol.40Issue(4)：348-352,5.DOI:10.19538/j.ek2025040616
以长期发热为主要表现的抗髓鞘少突胶质细胞糖蛋白抗体相关疾病6例
MOG antibody-associated disease with prolonged fever as the main presentation:report on six cases
丁秀芳 1金瑞峰 1李娟 1李志毅 1于春梅 1刘勇1
作者信息
- 1. 山东大学附属儿童医院(济南市儿童医院)神经内科,山东济南 250000
- 折叠
摘要
Abstract
A retrospective analysis was performed on the medical data of 6 children with positive anti-myelin oligodendrocyte glycoprotein(MOG)antibody and prolonged fever,who attended the Children's Hospital Affiliated to Shandong University from January 2021 to September 2021,in order to explore the clinical characteristics of MOG antibody-related diseases with prolonged fever as the main manifestation.The medical data included clinical manifestations,physical examinations,and auxiliary examinations.The results showed that all 6 cases had prolonged fever as the main clinical manifestation;only 1 case had a positive Babinski sign upon physical examination.In all 6 cases,the white blood cell(WBC)counts in blood routine were elevated,ranging from 19.8 to 34.0 × 109/L,with a neutrophil percentage of 77.4％to 89.9％;the erythrocyte sedimentation rate was between 61 and 105 mm/h,and the C-reactive protein was between 21.6 and 57.3 mg/L.WBC counts in the cerebrospinal fluid ranged from(15～180)×106/L.Inflammatory changes were observed in 3 cases in the brain magnetic resonance imaging(MRI),with 1 case showing inflammatory signal changes in the thalamus and cerebellum on day 35 of the disease course.Two cases had an MOG antibody titer of 1∶100,3 had an MOG antibody titer of 1∶32,and 1 had an MOG antibody titer of 1∶320.From this,it can be concluded that MOG antibody-related diseases can cause prolonged fever.关键词
发热,不明原因/脱髓鞘/抗髓鞘少突胶质细胞糖蛋白抗体相关疾病/脑炎Key words
fever,unknown origin/demyelination/anti-myelin oligodendrocyte glycoprotein antibody-associated disorders/encephalitis分类
医药卫生引用本文复制引用
丁秀芳,金瑞峰,李娟,李志毅,于春梅,刘勇..以长期发热为主要表现的抗髓鞘少突胶质细胞糖蛋白抗体相关疾病6例[J].中国实用儿科杂志,2025,40(4):348-352,5.
