中国兽医杂志2025，Vol.61Issue(5)：79-88,10.DOI:10.20157/j.cnki.zgsyzz.2025.05.010
A型塞内卡病毒蛋白功能和抗宿主先天免疫的研究进展
Research Progress on the Function of Senecavirus A(SVA)Protein and Its Antagonism of Host Innate Immunity
摘要
Abstract
Senecavirus A(SVA)can infect pigs of different age groups and is characterized by typical vesicular diseases,especially causing high mortality in neonatal piglets.SVA proteins,through interaction with host proteins,not only facilitate viral immune evasion but also manipulate programmed cell death,playing a significant role in viral replication.The main mechanisms by which SVA proteins achieve immune evasion include:(1)utilizing cysteine-containing aspartic acid protease(Caspase)pathways to degrade key receptors and adaptor proteins involved in the interferon signaling pathway,antagonizing interferon production;(2)directly targeting and cleaving proteins involved in the interferon signaling pathway and NF-κB signaling,inhibiting the transcription of interferon-stimulated genes(ISGs)and inflammatory factors,thereby antagonizing the host's antiviral immunity;(3)blocking the formation of stress granule(SG),utilizing the host's transcriptional and translational machinery to promote viral replication.Several studies have confirmed that multiple SVA proteins regulate host cell programmed death and degrade host antiviral factors through the autophagic pathway,thus promoting its replication.This paper systematically reviews the genomic structure of SVA,the function of its proteins,the various immune evasion pathways,and the mechanisms of inducing programmed cell death,providing theoretical support for further exploration of the infection mechanisms of SVA and the host's antiviral immune pathways.关键词
A型塞内卡病毒/先天免疫/细胞程序性死亡/免疫逃逸Key words
senecavirus A/innate immunity/programmed cell death/immune evasion分类
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石蒙蒙,张英硕,杨寒,孙亚威,陈陆,李永涛,于林洋..A型塞内卡病毒蛋白功能和抗宿主先天免疫的研究进展[J].中国兽医杂志,2025,61(5):79-88,10.基金项目
国家自然科学基金(30602781) （30602781）
河南省博士后科研启动基金(HN2022124) （HN2022124）
河南农业大学高层次人才专项支持基金(30501386) （30501386）
