中国药房2025，Vol.36Issue(10)：1153-1160,8.DOI:10.6039/j.issn.1001-0408.2025.10.01
常见侵入性诊疗操作预防性使用抗菌药物专家共识
Expert consensus on prophylactic use of antimicrobial agents in common invasive diagnostic and therapeutic procedures
摘要
Abstract
OBJECTIVE To provide the guiding recommendations for the prophylactic use of antimicrobial agents during the perioperative period in clinical practice,with the aim of enhancing the scientificity and rationality of antimicrobial agents.METHODS Based on National Clinical Classification and Coding System for Surgical Procedures Version 3.0,three categories of invasive diagnostic,therapeutic and interventional procedures that fell within the research scope of this consensus were screened out.These procedures were then consolidated according to key operative techniques,approaches,and recommendations.A search was conducted through Chinese and English databases for domestic and foreign guidelines/consensus documents and systematic reviews published in the past decade.The aim was to provide recommendations of prophylactic use of antimicrobial agents for procedures not covered in the Guiding Principles for Clinical Application of Antimicrobial Agents(2015 edition)(hereinafter referred to as the Guiding Principles)or to offer more detailed recommendations of prophylactic use of antimicrobial agents for procedures already included in the Guiding Principles.Consensus recommendations were ultimately formulated through the Delphi method and expert seminars,with a 70%agreement rate among experts(the consensus achievement rate)serving as the criterion for consensus attainment.RESULTS&CONCLUSIONS A total of 1 164 entries of invasive diagnostic and therapeutic procedures were included.After two rounds of the Delphi method and three rounds of expert seminars,this consensus was ultimately established.Compared to the Guiding Principles,this consensus explicitly proposes 23 recommendations advocating prophylactic use,21 recommendations against prophylactic use,and 23 recommendations against routine prophylaxis in invasive diagnostic and therapeutic procedures.Additionally,it specifies high-risk factor criteria and optimizes the duration of recommended medication.The consensus offers explicit guidance on the prophylactic use of antimicrobial agents in various scenarios of invasive diagnostic and therapeutic procedures.It is conducive to enhancing the rational use of antimicrobial agents,mitigating the emergence of bacterial resistance.Additionally,it may potentially contribute to improving the safety of invasive procedures and optimizing patient outcomes.关键词
侵入性诊疗操作/抗菌药物/预防/围操作期Key words
invasive diagnostic and therapeutic procedures/antimicrobial agents/prophylactic/perioperative period分类
药学引用本文复制引用
江苏省药学会感染药学专业委员会,邵华..常见侵入性诊疗操作预防性使用抗菌药物专家共识[J].中国药房,2025,36(10):1153-1160,8.基金项目
国家卫生健康委医院管理研究所医院药学高质量发展研究项目(No.NIHAYS2314) （No.NIHAYS2314）
