中国药房2025，Vol.36Issue(10)：1197-1201,5.DOI:10.6039/j.issn.1001-0408.2025.10.08
远志配伍对砂烫马钱子的减毒增效作用研究
Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica
摘要
Abstract
OBJECTIVE To explore the effects of Polygala tenuifolia compatibility on toxicity,anti-inflammatory and analgesic efficacy of sand-ironing Strychnos nux-vomica(SS).METHODS The preparation of SS single decoction,SS-P.tenuifolia core-removed(PC)(1∶2.5)or(1∶5)combined decoction,and SS-PC(1∶5)mixture were carried out to investigate their median lethal dose(LD50).Using aspirin as positive control,the number of writhing movements,analgesic rate,pain latency,ear swelling degree and inflammation inhibition rate induced by the above-mentioned medicinal liquids in mice were compared.The contents of the active and toxic components,strychnine and brucine,in the above-mentioned medicinal liquids were also determined.RESULTS The LD50 values of SS single decoction,SS-PC(1∶2.5)combined decoction,SS-PC(1∶5)combined decoction and SS-PC(1∶5)mixture were 302.00,614.47,1 445.44 and 1 778.28 mg/kg,respectively.Compared with control group,the number of writhing movements and ear swelling degree in the mice of the above-mentioned medicinal liquid groups were reduced or decreased significantly(P＜0.05 or P＜0.01);pain latency[at 90 and 120 minutes in the SS single decoction group,at 60 and 90 minutes in the SS-PC(1∶2.5)combined decoction group,and at 60,90,120 minutes in the SS-PC(1∶5)combined decoction group and SS-PC(1∶5)mixture group]was significantly prolonged(P＜0.05 or P＜0.01);analgesic rates of the respective medicinal liquids were 39.30%,70.87%,80.00%and 82.46%,and inflammation inhibition rates were 38.08%,57.89%,76.47%and 50.46%;analgesic and anti-inflammatory effects of combined decoction and mixture were generally better than those of the single decoction(P＜0.05 or P＜0.01).In the above-mentioned four medicinal liquids,the total contents of strychnine were 0.71%,0.42%,0.47%and 0.64%,and the total contents of brucine were 0.88%,0.63%,0.57%and 0.88%,respectively.CONCLUSIONS The combination of P.tenuifolia can reduce the toxicity of SS and enhance its anti-inflammatory and analgesic effects.Moreover,there is a tendency for the toxicity-reducing and efficacy-enhancing effects to increase with the increasing dosage of P.tenuifolia.Additionally,the combined decoction of SS and P.tenuifolia can reduce the contents of the active and toxic components,strychnine and brucine,in SS.关键词
砂烫马钱子/远志/减毒增效/急性毒性/抗炎/镇痛/士的宁/马钱子碱Key words
sand-ironing Strychnos nux-vomica/Polygala tenuifolia/toxicity-reducing and efficacy-enhancing effects/acute toxicity/anti-inflammatory/analgesia/strychnine/brucine分类
中医学引用本文复制引用
隋怡,冯果,刘刚,柳克艳,韦学浩,滕明刚,李玮,韩彩瑶,雷燕..远志配伍对砂烫马钱子的减毒增效作用研究[J].中国药房,2025,36(10):1197-1201,5.基金项目
国家中医药管理局省级中药炮制技术传承基地建设项目(No.国中医药科技中药便函[2015]132号) （No.国中医药科技中药便函[2015]132号）
中央本级重大增减支项目(No.2060302) （No.2060302）
贵州省高层次创新型人才项目(No.黔人领发[2020]4号) （No.黔人领发[2020]4号）
贵州省基本建设投资计划项目(No.黔发改投资[2015]542号) （No.黔发改投资[2015]542号）
贵州省研究生教育创新计划项目(No.2024YJSKYJJ357) （No.2024YJSKYJJ357）
贵州中医药大学国家与省级科技创新人才团队培育项目(No.贵中医TD合字[2024]001号) （No.贵中医TD合字[2024]001号）
