中国药房2025，Vol.36Issue(10)：1216-1220,5.DOI:10.6039/j.issn.1001-0408.2025.10.11
阿利西尤单抗联合阿托伐他汀对急性冠脉综合征患者PCI术后临床疗效和安全性的影响
Effects of alirocumab combined with atorvastatin on clinical efficacy and safety in patients with acute coronary syndrome after PCI
摘要
Abstract
OBJECTIVE To investigate the effects of alirocumab combined with atorvastatin on clinical efficacy and safety of patients with acute coronary syndrome(ACS)who underwent percutaneous coronary intervention(PCI).METHODS A total of 207 patients with ACS who underwent PCI in our hospital from January 2021 to December 2023 were randomly divided into alirocumab group,ezetimibe group and control group,with 69 cases in each group.All patients received routine thrombosis prevention and antihypertensive treatment after PCI.On this basis,patients in the control group were treated with atorvastatin(20 mg/time,once a day);patients in the ezetimibe group were treated with ezetimibe(10 mg/time,once a day)+atorvastatin(20 mg/time,once a day);patients in the alirocumab group were treated with alirocumab(75 mg/time,once every 2 weeks)+atorvastatin(20 mg/time,once a day).All patients in the three groups were treated for 8 weeks and followed up for another 6 months after treatment.The levels of cardiac function and lipid metabolism indices before and after treatment,as well as the occurrence of major adverse cardiovascular event(MACE)and other adverse drug reaction(ADR)during the follow-up period were compared among the three groups.RESULTS After treatment for 8 weeks,the levels of cardiac function and lipid metabolism indices in the three groups were significantly improved compared with those before treatment(P＜0.05).Compared with the control group and ezetimibe group,the left ventricular ejection fraction in the alirocumab group was significantly increased,and the left ventricular end-diastolic diameter(LVEDD)was significantly shortened(P＜0.05).Compared with control group,LVEDD of ezetimibe group was significantly shortened(P＜0.05),the levels of total cholesterol,triglyceride and low-density lipoprotein cholesterol in the alirocumab group and ezetimibe group were significantly decreased(P＜0.05).During the follow-up period,there was no significant difference in the total incidence of MACE and the total incidence of other ADR such as headache and abdominal pain among the three groups(P＞0.05).CONCLUSIONS Alirocumab combined with atorvastatin can significantly improve cardiac function and regulate lipid metabolism indices in patients with ACS after PCI without increasing the risk of MACE or other ADR.关键词
阿利西尤单抗/阿托伐他汀/急性冠脉综合征/经皮冠脉介入术/临床疗效/安全性/心功能/脂代谢/主要心血管不良事件Key words
alirocumab/atorvastatin/acute coronary syndrome/percutaneous coronary intervention/clinical efficacy/safety/cardiac function/lipid metabolism/major adverse cardiovascular event分类
医药卫生引用本文复制引用
郝翠君,王蕊,马逸平,张雪萍,刘亚男,秦少强..阿利西尤单抗联合阿托伐他汀对急性冠脉综合征患者PCI术后临床疗效和安全性的影响[J].中国药房,2025,36(10):1216-1220,5.基金项目
河北省自然科学基金项目(No.2022HBKJ00033) （No.2022HBKJ00033）
张家口市科技计划自筹经费项目(No.2322147D) （No.2322147D）
