中国药房2025，Vol.36Issue(10)：1277-1282,6.DOI:10.6039/j.issn.1001-0408.2025.10.22
NF-κB信号通路在急性肺损伤中的作用及中药干预研究进展
Research progress on the role of NF-κB signaling pathway in acute lung injury and TCM intervention
摘要
Abstract
Acute lung injury(ALI)is a common clinical inflammatory respiratory emergency with high morbidity and mortality,for which there is no effective and safe therapeutic drug.Nuclear factor-κB(NF-κB),as a classic inflammatory signaling pathway,can interact with upstream and downstream regulatory factors such as Toll-like receptor 4(TLR4),mitogen-activated protein kinase(MAPK),nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3),high mobility group box-1 protein 1(HMGB1),to jointly affect ALI.This review summarizes the latest research findings in recent years regarding the treatment of ALI through traditional Chinese medicine(TCM)interventions targeting NF-κB signaling pathways.It has been found that a variety of TCM monomers(danshensu methyl ester,salidroside total glycosides,berberine,Codonopsis pilosula polysaccharides,ursolic acid,chrysophanol,and polyphenols from longan seed kernels,etc.)and compound formulas(Resolving-dampness and defeating-toxins formula,Jinyin qingre oral liquid,Xuebijing injection,Combined treatment of lung and intestine,Huangqi baihe decoction,etc.)can modulate NF-κB signaling pathway,and can prevent and control ALI by inhibiting inflammation,improving oxidative stress,reducing apoptosis and modulating the intestinal flora in a multi-pathway manner.关键词
NF-κB信号通路/急性肺损伤/中药/机制Key words
NF-κB signaling pathway/acute lung injury/traditional Chinese medicine/mechanism分类
医药卫生引用本文复制引用
刘馥溧,巴元明..NF-κB信号通路在急性肺损伤中的作用及中药干预研究进展[J].中国药房,2025,36(10):1277-1282,6.基金项目
全国名老中医药专家传承工作室建设项目(No.国中医药人教函[2022]75号) （No.国中医药人教函[2022]75号）
湖北省科技重大项目(No.2022ACA003-03) （No.2022ACA003-03）
湖北中医药大学重大项目(No.2023ZDXM001) （No.2023ZDXM001）
