中国药房2025，Vol.36Issue(10)：1283-1288,6.DOI:10.6039/j.issn.1001-0408.2025.10.23
中药活性成分靶向线粒体凋亡途径抑制食管癌的研究进展
Research progress on active components of traditional Chinese medicine inhibiting esophageal carcinoma by targeting mitochondrial apoptosis pathway
摘要
Abstract
Esophageal carcinoma is a malignant disease with a high incidence rate and poor prognosis.The mitochondrial apoptosis pathway plays a pivotal role in the regulation of cell death and has become a focal point in current cancer therapeutics research.Various active components from traditional Chinese medicine(TCM)can target the mitochondrial apoptosis pathway to inhibit esophageal carcinoma,presenting as potential therapeutic agents for this disease.This paper summarizes relevant research on the inhibition of esophageal carcinoma by active components in TCM via targeting the mitochondrial apoptosis pathway.It has been found that flavonoids(casticin,icariin,luteolin,kaempferol,hesperetin,deguelin,etc.),terpenoids(oridonin,Jaridonin,artesunate,ethyl acetate fraction of pleurotus ferulatus triterpenoid,etc.),alkaloids(matrine,swainsonine,etc.),polyphenols(curcumin,epigallocatechin-3-gallate,corilagin,etc.),steroids(α-hederin,polyphyllin Ⅵ,etc.),phenols(optimized scorpion venom peptide CT-K3K7,gecko active polypeptide,etc.),volatile oils(cinnamaldehyde,α-asarone,etc.)and other active components from TCM can target the intrinsic mitochondrial apoptosis pathway,induce apoptosis in esophageal carcinoma cells,and inhibit their proliferation,invasion and migration by regulating oxidative stress,blocking the cell cycle,regulating signaling pathways such as PI3K/Akt and MAPK.关键词
中药/活性成分/食管癌/线粒体凋亡/细胞凋亡/作用机制Key words
traditional Chinese medicine/active components/esophageal carcinoma/mitochondrial apoptosis/cell apoptosis/mechanism of action分类
医药卫生引用本文复制引用
肖俊珂,慕晓艳,郭娇娇,杨上智,曹雪炜,郭志忠..中药活性成分靶向线粒体凋亡途径抑制食管癌的研究进展[J].中国药房,2025,36(10):1283-1288,6.基金项目
河南省科技攻关项目(No.242102311287) （No.242102311287）
河南省中医药科学研究专项(No.2022ZYZD11) （No.2022ZYZD11）
上海中医药大学附属龙华医院"龙医学者"临床科技创新项目(No.KC2022015) （No.KC2022015）
