中国医科大学学报2025，Vol.54Issue(5)：414-418,5.DOI:10.12007/j.issn.0258-4646.2025.05.006
精子高DNA可染性与精液常规参数的相关性
Relationship between high DNA stainability of sperm and routine semen parameters
摘要
Abstract
Objective To investigate the relationship between high DNA stainability(HDS)and routine semen parameters.Methods Semen samples were collected from 396 men of childbearing age who were admitted to our department.Correlations of HDS with routine semen parameters and age were analyzed.Multiple linear regression analysis was performed to identify the routine semen parameters that had the greatest influence on HDS.The correlation of HDS and DNA fragmentation index(DFI)with routine semen parameters and age in 244 patients with teratozoospermia was analyzed.The 244 patients were divided into extremely severe,severe,moderate,and mild teratozoospermia groups,and differences in HDS,DFI,and routine semen parameters were compared among the four groups.Results HDS was negatively correlated with total sperm count,sperm concentration,sperm progressive motility,and normal sperm morphology rate(NSMR)(P<0.01).After adjusting for potential confounders,including total sperm count,sperm concentration,sperm progressive motility,NSMR,and DFI,NSMR had the most significant negative effect on HDS(P<0.05).In the 244 patients with teratozoospermia,HDS was negatively correlated with NSMR(P<0.01)and positively correlated with the percentage of sperm head and tail abnormalities(P<0.05),while DFI was positively correlated with the percentage of sperm tail abnormalities(P<0.01).There was a significant difference in the percentage of sperm head abnormalities among the four teratozoospermia groups.The more severe the malfor-mation,the higher the percentage of sperm head abnormalities was(P<0.001).HDS in the extremely severe teratozoospermia group was significantly higher than that in the mild and moderate teratozoospermia groups(P<0.05).No significant differences in DFI were found among the four groups(P>0.05).Conclusion HDS was closely correlated with routine semen parameters and was a crucial biomarker for assessing sperm quality,particularly the extent of sperm head abnormalities.关键词
高DNA可染性/DNA碎片指数/精液常规参数/精子头部畸形Key words
high DNA stainability/DNA fragmentation index/routine semen parameter/sperm head abnormality分类
临床医学引用本文复制引用
关小川,马明,张宁,白雪,刘星池,周静,于月新..精子高DNA可染性与精液常规参数的相关性[J].中国医科大学学报,2025,54(5):414-418,5.基金项目
辽宁省科学技术计划(2023JH2/101700091) （2023JH2/101700091）
