中国医疗美容2025，Vol.15Issue(4)：122-126,5.DOI:10.19593/j.issn.2095-0721.2025.04.033
两种美容填充物对血管内引发栓塞差异性研究
A comparative study on the intravascular embolism induced by two classical cosmetic fillers
Khan Aawrish 1朱柏年 2齐莉莉 1崔海燕1
作者信息
- 1. 同济大学医学院 同济医院 整形美容外科,上海,200092||同济大学医学院 同济大学整形美容医学研究所,上海,200092
- 2. 南京华韩奇致美容医院,江苏 南京,210000
- 折叠
摘要
Abstract
Objective To investigate the impact of intravascular injection of two cosmetic fillers,namely hyaluronic acid and Ellanse,on the severity of embolism.Methods The rabbit auricular artery was selected as the experimental model to establish a flap necrosis model by ligating three dorsal auricular flaps,followed by intravascular embolization induced by injecting equal amounts of hyaluronic acid and Ellansé into the artery.Fluorescence labeling and in vivo imaging were employed to monitor filler displacement during injection,while flap necrosis and blood flow at the ischemic site were assessed immediately after surgery,on day 3 and day 7 post-surgery.H&E histological analysis was conducted to evaluate filler degradation and local inflammatory response.Results In vivo imaging of small animals revealed that compared to Ellansé,hyaluronic acid fillers were more widely dispersed in the ear margin after intravascular injection and more prone to displacement within blood vessels.Laser speckle imaging demonstrated a rapid decrease in flap blood flow to 7.65%±0.37%of initial levels following ligation,with recovery to 64.75%±7.29%in the control group at 7 days post-operation;however,blood flow recovery was significantly impeded in both the hyaluronic acid and Ellansé groups(47.83%±6.41%and 46.56%±2.11%,respectively).Gross observation indicated local flap necrosis at the distal end after 7 days of intravascular injection with either hyaluronic acid or Ellansé,while histological analysis of H&E staining showed vessel expansion following injection with incomplete tamponade degradation observed at the distal end of the auricular artery for both substances,indicating their propensity for shifting within blood vessels.Conclusions Compared to Ellansé,hyaluronic acid exhibits a higher susceptibility to intravascular translocation following intravascular injection.Both substances can induce severe vascular obstruction and reduce blood flow velocity.Macroscopic examination revealed that this type of intravascular blockage leads to local flap necrosis.Histological evaluation using H&E staining demonstrated that both hyaluronic acid and Ellansé cannot be completely degraded within the blood vessel without external intervention,thereby causing certain damage to the vasculature.关键词
透明质酸/Ellansé/填充物/血管栓塞/皮瓣坏死Key words
hyaluronic acid/Ellansé/aesthetic medicine/fillers/intravascular embolism/flap necrosis引用本文复制引用
Khan Aawrish,朱柏年,齐莉莉,崔海燕..两种美容填充物对血管内引发栓塞差异性研究[J].中国医疗美容,2025,15(4):122-126,5.
