中国药理学与毒理学杂志2025，Vol.39Issue(5)：361-369,9.DOI:10.3867/j.issn.1000-3002.2025.08272
N6-甲基腺苷修饰在调控肝药物代谢个体差异中的研究进展
Novel insights into the role of N6-methyladenosine modification in regulating individual differences in hepatic drug metabolism
摘要
Abstract
Large inter-individual and intra-individual differences in the expression and activity of drug-metabolizing enzymes(DMEs)contribute to unpredictable drug response and toxicity,which is a challenge facing precision medicine.Nuclear receptor-mediated transcriptional regulation and epigenetic mechanisms including histone modifications,non-coding RNAs,and DNA methylation can help to explain the individual variability in DME expressions.However,several questions remain unanswered.Recently,epitranscriptomics,an emerging field,provides new insights into the regulation of gene expression.As the most abundant RNA modification in eukaryotes,N6-methyladenosine(m6A)modifi-cation plays key roles in various physiological and pathological processes.This review summarizes the recent progress in m6A modification-mediated individual variability in DME expression in terms of the role of m6A modification in regulating basal expression of DMEs,crosstalk between m6A modification and nuclear receptors during the ontogeny of DMEs,and the contribution of m6A modification to xenobi-otic exposure-mediated changes in DME expression.This review aims to provide data for the elucida-tion of individual variations in drug metabolism in clinic.关键词
N6-甲基腺苷修饰/RNA修饰/药物代谢酶/个体差异Key words
N6-methyladenosine modification/RNA modification/drug-metabolizing enzymes/indi-vidual difference分类
药学引用本文复制引用
程昊天,李勤浩,李明珠,王沛..N6-甲基腺苷修饰在调控肝药物代谢个体差异中的研究进展[J].中国药理学与毒理学杂志,2025,39(5):361-369,9.基金项目
河南省自然科学基金(232300421293) （232300421293）
河南省博士后面上项目(202101015) （202101015）
河南省大学生创新创业训练计划项目(202210459187)Natural Science Foundation of Henan(232300421293) （202210459187）
Postdoctoral Research Grant in Henan Province(202101015) （202101015）
Innovation and Entrepreneurship Training Program for University Students in Henan Province(202210459187) （202210459187）
