中国药理学与毒理学杂志2025，Vol.39Issue(5)：391-400,10.DOI:10.3867/j.issn.1000-3002.2025.08278
抗生素耐药基因接合转移的非抗生素类环境污染物影响及机制研究进展
Research progress in effects of non-antibiotic environmental pollutants on the conjugative transfer of antibiotic resistance genes
王佳琪 1薛斌 2曹高芳 3谌志强 2李超2
作者信息
- 1. 滨州医学院公共卫生学院，山东 烟台 264003||军事医学研究院，天津 300050
- 2. 军事医学研究院，天津 300050
- 3. 滨州医学院公共卫生学院，山东 烟台 264003
- 折叠
摘要
Abstract
The spread of antibiotic resistance genes(ARGs)poses a serious threat to global public health.Recent studies have shown that in addition to the difficulty in antibiotic selection,many non-anti-biotic environmental pollutants,such as microplastics,heavy metals,nanomaterials and non-antibiotic drugs,can accelerate the spread of ARGs.This paper begins by outlining the influence of non-antibiotic environmental pollutants on the conjugative transfer of ARGs.Then,the mechanisms of ARGs are analyzed from the perspective of molecular biology,which include inducing the generation of large amounts of reactive oxygen radicals,triggering cellular oxidative stress,increasing intercellular contact,altering the permeability of cell membranes,affecting energy metabolism,triggering group sensing effects,and regulating the expression of genes related to the transfer of ARGs.Finally,the limitations of current studies are presented,and tips are given about future research.In conclusion,the effects of non-antibi-otic environmental pollutants on the spread and dispersal of ARGs need to be studied more extensively.关键词
抗生素耐药基因/接合转移/质粒/活性氧Key words
antibiotic resistance genes/conjugative transfer/plasmid/reactive oxygen species分类
药学引用本文复制引用
王佳琪,薛斌,曹高芳,谌志强,李超..抗生素耐药基因接合转移的非抗生素类环境污染物影响及机制研究进展[J].中国药理学与毒理学杂志,2025,39(5):391-400,10.
