中国药物经济学2025，Vol.20Issue(4)：15-21,28,8.DOI:10.12010/j.issn.1673-5846.2025.04.003
阿瑞匹坦注射液与注射用福沙匹坦双葡甲胺相比预防中高度致吐性化疗相关性恶心呕吐的药物经济学评价
Pharmacoeconomic Evaluation of Aprepitant Injection compared with Fosaprepitant Dimeglumine for Injection for the Prevention of Moderately and Highly Emetogenic CINV
向衡 1王李婷 1彭烨 1孟科辉 1谭重庆1
作者信息
- 1. 中南大学湘雅二医院药学部,长沙 410011
- 折叠
摘要
Abstract
Objective To evaluate the economics of Aprepitant injection compared with Foxapitan Dimegraumine for injection in the prevention of moderate and high emetogenic chemotherapy-associated nausea and vomiting(CINV).Methods From the perspective of the Chinese healthcare system,we constructed a decision tree model incorporating four health states-complete response(CR)in the acute phase,incomplete response(IR)in the acute phase,CR in the delayed phase,and IR in the delayed phase-to conduct a cost-effectiveness analysis.The incremental cost-effectiveness ratio(ICER)was compared against the willingness-to-pay(WTP)threshold to evaluate the economic value of Aprepitant Injection versus Fosaprepitant Dimeglumine for Injection in preventing moderate-to-high emetogenic chemotherapy-induced nausea and vomiting(CINV).Both one-way sensitivity analysis and probabilistic sensitivity analysis were employed to assess parameter uncertainties.Results Base-case analysis revealed that Aprepitant Injection(¥139 per 130 mg)provided an incremental gain of 0.000 49 quality-adjusted life-years(QALYs)compared to Fosaprepitant Dimeglumine for Injection(¥136 per 150 mg),while reducing total costs by ¥299.Demonstrating the cost-effectiveness of Aprepitant Injection.One-way sensitivity analysis identified the utility value of the complete response(CR)state with Aprepitant Injection as the most influential parameter on ICER.Probabilistic sensitivity analysis further indicated a 99%probability of Aprepitant Injection being cost-effective at a WTP threshold of ¥85 698 per QALY.Conclusion Aprepitant injection is a safe,effective,economical and convenient prevention of moderately and highly emetogenic CINV when the price is reduced to RMB 139/130 mg.关键词
阿瑞匹坦注射液/注射用福沙匹坦双葡甲胺/化疗相关性恶心呕吐/药物经济学Key words
Aprepitant injection/Fosaprepitant dimeglumine for injection/Chemotherapy induces nausea and vomiting/Pharmacoeconomic分类
医药卫生引用本文复制引用
向衡,王李婷,彭烨,孟科辉,谭重庆..阿瑞匹坦注射液与注射用福沙匹坦双葡甲胺相比预防中高度致吐性化疗相关性恶心呕吐的药物经济学评价[J].中国药物经济学,2025,20(4):15-21,28,8.
