摘要
Abstract
Objective To explore the effect of general anesthesia with remimazolam in patients undergoing laparoscopic radical surgery of colorectal cancer.Methods A total of 100 patients who underwent laparoscopic radical resection for colorectal cancer treated in Binzhou People's Hospital from May 2023 to June 2024 were selected and divided into observation group(n=50)and control group(n=50)according to random number table method.The control group was given propofol general anesthesia,and the observation group was given remimazolam general anesthesia.Anesthesia related indexes,vital signs,recovery quality,vasoactive drug use and adverse reactions were compared between the two groups.Results There was no statistically significant difference in the duration of anesthesia,recovery,extubation,and stay in the anesthesia recovery room(PACU)between the two groups(P＞0.05).Immediately after intubation(T1),skin incision(T2),and the end of the operation(T3)in both groups,the cerebral state index(CSI),mean arterial pressure(MAP),and heart rate(HR)decreased compared with those before anesthesia induction(T0)(P＜0.05),but there was no statistically significant comparison of HR between the two groups at T1(P＞0.05).At T1,the MAP of the observation group was higher than that of the control group(P＜0.05).At T2 and T3,the MAP and HR of the observation group were higher than those of the control group(P＜0.05).There was no statistically significant difference in CSI between the two groups at T1,T2 and T3(P＞0.05).The scores of the 15-item Quality of Recovery Scale(QoR-15)at each postoperative period in both groups decreased compared with those before anesthesia(P＜0.05),but the scores in the observation group were higher than those in the control group(P＜0.05).The utilization rate of vasoactive drugs was statistically analyzed.It was 22.00%(11/50)in the observation group,which was lower than 42.00%(21/50)in the control group(P＜0.05).The incidences of hypotension and bradycardia in the observation group were lower than those in the control group(P＜0.05).Conclusion The application of remimazolam general anesthesia in patients undergoing laparoscopic radical resection of colorectal cancer can reduce the impact on vital signs,improve recovery quality,reduce the use of vasoactive drugs,and decrease the occurrence of hypotension and bradycardia.关键词
结直肠癌/腹腔镜根治术/瑞马唑仑/全身麻醉Key words
Colorectal cancer/Laparoscopic radical surgery/Remimazolam/General anesthesia分类
临床医学
