摘要
Abstract
Objective To explore the clinical effect of isosorbide mononitrate combined with clopidogrel bisulfate on angina pectoris caused by coronary atherosclerotic heart disease(CHD).Methods Eighty-seven patients with CHD angina pectoris admitted to Tai'an Maternal and Child Health Hospital from February 2021 to February 2023 were selected as the study objects,and were divided into control group(n=43)and observation group(n=44)by random number table method.The control group was treated with isosorbide mononitrate,and the observation group was treated with isosorbide mononitrate combined with clopidogrel bisulfate tablets.The frequency and duration of angina pectoris,cardiac function,inflammatory factors and adverse reactions were compared between the two groups.Results After treatment,the frequency of angina pectoris in the observation group was less than that in the control group,and the duration of angina pectoris was shorter than that in the control group,with statistical significance(P＜0.05).After treatment,left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)in observation group were lower than those in control group,and left ventricular ejection fraction(LVEF)was higher than that in control group,the difference was statistically significant(P＜0.05).After 48 h of treatment,the levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)in observation group were lower than those in control group,with statistical significance(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Isosorbide mononitrate combined with clopidogrel bisulfate has a significant effect,which can effectively reduce the frequency and duration of angina pectoris in CHD patients,improve cardiac function and inflammatory response,and has a high safety.关键词
单硝酸异山梨酯/硫酸氢氯吡格雷/冠状动脉粥样硬化性心脏病/心绞痛Key words
Isosorbide mononitrate/Clopidogrel bisulfate/Coronary heart disease/Angina pectoris分类
医药卫生
