摘要
Abstract
Objective:To investigate the clinical efficacy and safety of reduced glutathione injection in the treatment of isoniazid and rifampicin-induced drug-induced liver injury.Methods:From June 2022 to June 2024,80 patients with liver injury occurring during treat-ment with isoniazid and rifampicin admitted to our hospital were enrolled and divided into a control group(n=40)and an experimental group(n=40)using a convenient grouping method.The control group was treated with polyene phosphatidylcholine,while the experimen-tal group received additional reduced glutathione based on the control group's treatment regimen.Both groups were treated for 4 weeks,and clinical efficacy,liver function,liver fibrosis indicators,and incidence of adverse reactions were observed.Results:After interven-tion,the effective rate in the experimental group was 95.00％,higher than 80.00％ in the control group(P＜0.05).After intervention,liver function indicators including AST,ALT,ALP,GGT,and TBIL decreased in both groups,with lower levels in the experimental group compared to the control group(P＜0.05).After intervention,liver fibrosis indicators including PC-Ⅲ,Ⅳ-C,LN,and HA de-creased in both groups,with lower levels in the experimental group compared to the control group(P＜0.05).During treatment,the inci-dence of adverse reactions in the experimental group was 2.5％,lower than 20.00％ in the control group(P＜0.05).Conclusion:Re-duced glutathione injection demonstrates significant clinical efficacy and high safety in the treatment of isoniazid and rifampicin-induced drug-induced liver injury,warranting further promotion and application in clinical practice.关键词
还原型谷胱甘肽/异烟肼/利福平/药物性肝损伤/临床疗效/安全性Key words
Reduced glutathione/Isoniazid/Rifampicin/Drug-induced liver injury/Clinical efficacy/Safety分类
药学
