中国药物评价2025，Vol.42Issue(2)：121-125,5.
百蕊颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮的临床效果分析
Effect of Combining Bairui Granules with Montelukast Sodium in Treating Children with Cough Variant Asthma
摘要
Abstract
Objective:To analyze the effect of Baier Granules combined with Montelukast sodium in the treatment of children with cough variant asthma(CVA).Methods:A total of 91 children with CVA in the Zhengzhou Maternal and Child Health Hospital from September 2023 to September 2024 were selected.Patients were divided into control group and observation group according to different treatment plans.Among them,46 cases treated with Montelukast sodium were in the control group,and 45 cases treated with Bairui Granules combined with Montelukast sodium were in the observation group.The clinical efficacy,incidence of adverse reactions,and clinical symptom improvement after 4 weeks of treatment were compared between the two groups,as well as the lung function and serum inflammatory factor levels before and after 4 weeks of treatment.Results:The total clinical effective rate of the observation group(88.89％)was higher than that of the control group(71.74％)(P＜0.05).After 4 weeks of treatment,the observation group showed better improvement in wheezing,body temperature,cough,sore throat,and asthma than the control group(P＜0.05).After 4 weeks of treatment,the forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC),and FEV1/FVC levels in the observation group were higher than those in the control group(P＜0.05).After 4 weeks of treatment,the levels of interleukin(IL)-6,tumor necrosis factor(TNF)-α,interleukin(IL)-4,and interleukin(IL)-5 in the observation group were decreased more significantly than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the groups(P＞0.05).Conclusion:The combination of Bairui Granules and Montelukast sodium has significant therapeutic effects in treating children with CVA,which can inhibit inflammatory reactions in the body,improve clinical symptoms and lung function,and has certain safety.关键词
百蕊颗粒/孟鲁司特钠/咳嗽变异性哮喘/临床效果Key words
Bairui Granules/Montelukast sodium/Cough variant asthma/Clinical Effect分类
药学引用本文复制引用
赵向德,张瑞,王莹莹..百蕊颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮的临床效果分析[J].中国药物评价,2025,42(2):121-125,5.基金项目
2024年郑州市医疗卫生领域科技创新指导计划项目(2024YLZDJH343) （2024YLZDJH343）
郑州市妇幼保健院2023年院内科研项目(YNKY202303) （YNKY202303）
