摘要
Abstract
Objective:To investigate the application value of combined detection of serum-related inflammatory markers[interleukin-6(IL-6),procalcitonin(PCT),and serum amyloid A(SAA)]in the early diagnosis of neonatal sepsis(NS)and predicting the severity of the disease.Method:A total of 126 patients with NS(NS group)who were hospitalized in People's Hospital of Rizhao from January 2022 to June 2024 were selected as the study subjects,and according to the neonatal critical illness score(NCIS),there were 61 cases in non-critical group,38 cases in critical group and 27 cases in extremely critical group,and 50 healthy neonates born in the hospital during the same period were selected as the control group,and serum IL-6,PCT and SAA were measured in all the enrolled neonates.Result:The serum levels of IL-6,PCT,and SAA in the NS group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The combined detection of serum IL-6,PCT,and SAA for the diagnosis of NS demonstrated a sensitivity,accuracy,and negative predictive value of 85.71%,86.36%,and 70.97%,respectively,which were significantly higher than those of individual tests,the differences were statistically significant(P<0.05).There were statistically significant differences in serum IL-6,PCT,and SAA levels among the NS three groups(P<0.05),and the serum levels of IL-6,PCT,and SAA in non-critical group,critical group and extremely critical group increased in turn(P<0.05).Spearman correlation analysis showed that serum levels of IL-6,PCT,and SAA were significantly positively correlated with the severity of NS disease(r=0.852,0.793,0.707,P<0.05).Conclusion:Serum IL-6,PCT,and SAA can be used as hematological indicators for the diagnosis of NS,and the combined detection of the three indicators can significantly improve the diagnostic value,and can also predict the severity of the disease according to their expression levels.关键词
新生儿败血症/白细胞介素-6/降钙素原/血清淀粉样蛋白A/血液学诊断/预测Key words
Neonatal sepsis/IL-6/PCT/SAA/Hematology diagnosis/Prediction
