中国医学创新2025，Vol.22Issue(14)：145-149,5.DOI:10.3969/j.issn.1674-4985.2025.14.032
血清NT-proBNP、sCD14、SAA在慢性阻塞性肺疾病中的应用
Application of Serum NT-proBNP,sCD14,and SAA in Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective:To explore the correlation between serum N-terminal brain natriuretic peptide precursor(NT-proBNP),soluble leukocyte differentiation antigen 14(sCD14),serum amyloid A(SAA)and pulmonary function in patients with chronic obstructive pulmonary disease(COPD)and the diagnostic value of the disease.Method:A total of 150 COPD patients admitted to Jiujiang NO.1 People's Hospital from May 2022 to May 2024 were selected and divided into stable group(n=58)and acute exacerbation COPD(AECOPD)group(n=92)according to disease progression.Meanwhile,60 healthy adults who underwent physical examination in our hospital during the same period were collected as the control group.Serum levels of NT-proBNP,sCD14,SAA,forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in one second/forced vital capacity(FEV1/FVC)were compared among the three groups.Pearson correlation coefficient and receiver operating characteristic(ROC)curve were used to analyze the correlation of NT-proBNP,sCD14 and SAA with lung function and their diagnostic efficacy in COPD.Result:The levels of serum NT-proBNP,sCD14 and SAA in stable group and AECOPD group were higher than those in control group,and the levels of serum NT-proBNP,sCD14 and SAA in AECOPD group were higher than those in stable group(P<0.05).FVC,FEV1/FVC and PEF in stable group and AECOPD group were lower than those in control group,and FVC,FEV1/FVC and PEF in AECOPD group were lower than those in stable group(P<0.05).The levels of serum NT-proBNP,sCD14 and SAA were negatively correlated with FVC,FEV1/FVC and PEF(P<0.05).The AUC of serum NT-proBNP,sCD14 and SAA combined diagnosis of COPD was significantly higher than that of single diagnosis of NT-proBNP,sCD14 and SAA(Z=2.827,3.023,3.848,P<0.05).Conclusion:NT-proBNP,sCD14 and SAA were highly expressed in the serum of COPD patients,and were negatively correlated with the severity of the disease and pulmonary function indicators.The combined detection of the three indicators has high diagnostic value and can be used for the assessment of patients'disease conditions.关键词
N末端脑钠肽前体/可溶性白细胞分化抗原14/血清淀粉样蛋白A/慢性阻塞性肺疾病Key words
N-terminal brain natriuretic peptide precursor/Soluble leukocyte differentiation antigen 14/Serum amyloid A/Chronic obstructive pulmonary disease引用本文复制引用
成诚,潘玲..血清NT-proBNP、sCD14、SAA在慢性阻塞性肺疾病中的应用[J].中国医学创新,2025,22(14):145-149,5.基金项目
江西省卫健委科技计划项目(202210268) （202210268）
