中国医学创新2025，Vol.22Issue(15)：180-184,5.DOI:10.3969/j.issn.1674-4985.2025.15.040
MAGL介导内源性大麻素系统参与PSD发生的研究进展
Advances in MAGL Mediated Endogenous Cannabinoid System Involved in PSD
摘要
Abstract
Post stroke depression(PSD),as a common sequelae manifestation after stroke,has a negative impact on the treatment and rehabilitation of motor and cognitive impairments in patients after stroke,and significantly increases the probability of stroke recurrence and death.The endogenous cannabinoid system(ECS)is an indispensable part of emotion regulation and is related to the pathogenesis of stroke and depression.Monoacylglycerol lipase(MAGL),as the most important hydrolase of ECS,is regarded as the most promising drug target for the treatment of neuropsychiatric diseases.This article analyzes the correlation between MAGL and PSD,provides a new perspective for exploring the pathogenesis of PSD and the development of anti-PSD drugs.关键词
脑卒中/抑郁/脑卒中后抑郁/内源性大麻素系统/单酰基甘油脂肪酶Key words
Stroke/Depression/Post stroke depression/Endogenous cannabinoid system/Monoacylglycerol lipase引用本文复制引用
宋维伟,田荣娜,李希芝,李斌..MAGL介导内源性大麻素系统参与PSD发生的研究进展[J].中国医学创新,2025,22(15):180-184,5.基金项目
山东省医药卫生科技发展计划项目(2019WS322) （2019WS322）
