中国医学前沿杂志（电子版）2025，Vol.17Issue(4)：1-6,6.DOI:10.12037/YXQY.2025.04-01
基因编辑异种器官移植技术的发展及趋势思考
Research progress and perspective of gene-edited organs in xenotransplantation technology
焦国慧 1陈静瑜2
作者信息
- 1. 国家药品监督管理局医疗器械技术审评中心,北京 100081
- 2. 南京医科大学附属无锡人民医院 江苏省肺移植中心 无锡市器官移植研究院,江苏 无锡 214023
- 折叠
摘要
Abstract
With the progress of organ transplantation technology,more and more patients with end-stage diseases have gained new life.In order to meet the global demand for organs,xenotransplantation technology has been developed rapidly in recent years.Transplantation of non-human primate(NHP)derived kidneys,hearts and livers has been developed,with increasing number of trials using pig-derived organs.The gene editing technology based on clustered regularly interspaced short palindromic repeats(CRISPR)can achieve the modification of multiple gene loci.Researchers are developing gene-edited pig lines by altering the response of natural antibodies to the vascular endothelium of porcine organs,activating the complement system and intrinsic immune cells,and inducing coagulation cascade,inflammatory and adaptive immune responses.The first human trial of xenogeneic heart transplantation was carried out in early 2022.The technology of xenotransplantation has gradually entered the clinical practice,but it is also facing many challenges in medicine,ethics and supervision.Researchers should be more cautious in evaluating the quality of medical products,and all parties should strengthen communication and exchange to promote the development of global transplantation.This paper summarizes the technological development route in this field,and ponders over the future development trend and challenges.关键词
异种移植/基因编辑/器官移植/质量/评价Key words
Xenotransplantation/Gene editing/Organ transplantation/Quality/Evaluation引用本文复制引用
焦国慧,陈静瑜..基因编辑异种器官移植技术的发展及趋势思考[J].中国医学前沿杂志（电子版）,2025,17(4):1-6,6.
