中国医学前沿杂志（电子版）2025，Vol.17Issue(4)：37-47,11.DOI:10.12037/YXQY.2025.04-07
循环胆汁酸影响多囊卵巢综合征患者心血管疾病的危险因素
Circulating bile acids influence the risk factors of cardiovascular diseases in patients with polycystic ovary syndrome
摘要
Abstract
Objective To investigate the alterations of bile acids in overweight/obese polycystic ovary syndrome(PCOS)after the intervention with calorie-restricted diet(CRD)or dulaglutide combined with CRD and its association with cardiovascular disease risk factors.Methods This trial was a randomized,controlled,open-label study conducted in Shanghai Tenth People's Hospital between May 2021 and May 2022.A total of overweight/obese PCOS patients were randomly assigned to CRD alone(n=33)or dulaglutide combined with CRD(n=35)within 6 months.The serum bile acid profiles before and after CRD or dulaglutide combined with CRD treatment were detected by a developed liquid chromatography-tandem mass spectrometry(LC-MS/MS)method.Additionally,the correlation between different bile acid metabolites and risk factors for cardiovascular diseases in PCOS patients was explored.Results After the CRD treatment,lithocholic acid(LCA)and taurolithocholic acid(TLCA)significantly increased in the serums of overweight/obese PCOS patients.The combination of dulaglutide and CRD led to significant differences in the primary conjugated bile acids levels.Moreover,dulaglutide combined with CRD treatment dramatically increased circulating TLCA,cholic acid(CA),and LCA levels,while serum glycochenodeoxycholic acid(GCDCA)decreased.Correlation analysis indicated that changes of bile acid metabolites in overweight/obese PCOS patients after treatment were associated with the alterations of clinical characteristics which were related to cardiovascular diseases.Conclusions Our data suggested that CRD or the combination of dulaglutide and CRD altered bile acids metabolism in overweight/obese PCOS patients.Bile acids metabolism was associated with the improvement of clinical parameters such as risk factors for cardiovascular diseases.关键词
胆汁酸/心血管疾病/多囊卵巢综合征/代谢组学/限制热量饮食Key words
Bile acids/Cardiovascular diseases/Polycystic ovary syndrome/Metabolomics/Calorie-restricteddiet引用本文复制引用
吴静娜,蔡美丽,王楠,秦开心,赵媛,朱亦堃,罗静,张曼娜,李晋..循环胆汁酸影响多囊卵巢综合征患者心血管疾病的危险因素[J].中国医学前沿杂志（电子版）,2025,17(4):37-47,11.基金项目
国家自然科学基金(82270915) （82270915）
山西省科技创新团队专项资金(202304051001021) （202304051001021）
山西省高等教育"百亿工程"科技引导项目(BYJL010) National Natural Science Foundation of China(82270915) （BYJL010）
Special Fund for Science and Technology Innovation Teams of Shanxi Province(202304051001021) （202304051001021）
Shanxi Province Higher Education"Billion Project"Science and Technology Guidance Project(BYJL010) （BYJL010）
