中国癌症防治杂志2025，Vol.17Issue(2)：207-214,8.DOI:10.3969/j.issn.1674-5671.2025.02.12
胃癌新辅助化疗患者术前营养干预的最佳证据总结
Best evidence of preoperative nutritional intervention in neoadjuvant chemotherapy for gas-tric cancer patients
摘要
Abstract
Objective To retrieve,synthesize and evaluate the evidence on preoperative nutritional intervention for gastric cancer patients undergoing neoadjuvant chemotherapy(NACT),and to provide an evidence-based foundation for clinical practice.Methods Following the"6S"evidence resource model,systematic searches were conducted in the databases or websites including BMJ Best Practice,UpToDate,the Guidelines International Network(GIN),Scottish Intercollegiate Guidelines Network(SIGN),European Society for Clinical Nutrition and Metabolism(ESPEN),American Society for Parenteral and Enteral Nutrition(ASPEN),Chinese Society of Parenteral and Enteral Nutrition(CSPEN),Chinese Society of Clinical Oncology(CSCO),PubMed,Web of Science,Ovid,Medline,Cochrane Library,JBI Library,China Biomedical Literature Database(CBM),Chinese National Knowledge Infrastructure(CNKI),Wanfang Database for Chinese/English literature on nutritional management in gastric cancer NACT patients.Literature types included clinical decision-making,guidelines,expert consensuses,systematic reviews,Meta-analyses,evidence summaries,and randomized controlled trials with a search timeframe from database inception to May 2024.Two researchers independently performed literature screening and quality assessment.After consulting evidence-based nursing experts,evidence extraction and synthesis were conducted for qualified studies.Results A total of 20 articles were included:2 clinical decisions,9 guidelines,3 expert consensuses,4 systematic reviews,and 2 randomized con-trolled trials.Evidence was synthesized into 27 recommendations across 5 themes:multidisciplinary collaboration,comprehensive nutrition assessment,nutritional interventions strategies,chemotherapy gastrointestinal symptom management,nutrition education and monitoring.Conclusions This study synthesizes 27 pieces of best evidence on preoperative nutritional intervention for gastric cancer NACT patient across 5 domains,demonstrating strong practicability and scientific rigor.These findings provide actionable guidance for personalized nutritional management in clinical settings.关键词
胃癌/新辅助化疗/营养干预/循证护理/最佳证据Key words
Gastric cancer/Neoadjuvant chemotherapy/Nutritional intervention/Evidence-based nursing/Best evidence分类
医药卫生引用本文复制引用
孙蜓,刘家欢,蔡丽娜,郑恒宇,叶向红..胃癌新辅助化疗患者术前营养干预的最佳证据总结[J].中国癌症防治杂志,2025,17(2):207-214,8.基金项目
军事医学创新工程项目(18CXZ040) （18CXZ040）
蚌埠医学院研究生科研创新计划项目(Byycx23021) （Byycx23021）
