中国癌症防治杂志2025，Vol.17Issue(2)：244-250,7.DOI:10.3969/j.issn.1674-5671.2025.02.17
大分割放疗联合免疫治疗在头颈部鳞状细胞癌中的研究进展
Research progress of hypofractionated radiotherapy combined with immunotherapy in head and neck squamous cell carcinoma
摘要
Abstract
Head and neck cancer ranks as the eighth most common cancer globally,with over 90％histologically classified as head and neck squamous cell carcinoma(HNSCC).In recent years,with the rapid advancement of immunotherapy,the combination of radiotherapy and immunotherapy has emerged as a prominent research focus in the treatment of HNSCC.Compared with conventional fractionation radiotherapy,hypofractionated radiotherapy demonstrates superior efficacy in triggering antitumor immune responses.Additionally,the combination of hypofractionated radiotherapy and immunotherapy has shown favorable clinical outcomes with acceptable safety profiles in recurrent/metastatic HNSCC.In the neoadjuvant therapy for locally advanced HNSCC,it also shows significant tumor reduction and down-staging effects.This review summarizes recent advances on hypofractionated radiotherapy combined with immunotherapy for HNSCC,aiming to provide novel insights for the treatment of HNSCC.关键词
头颈部鳞状细胞癌/放射治疗/大分割放疗/免疫治疗Key words
Head and neck squamous cell carcinoma/Radiotherapy/Hypofractionated radiotherapy/Immunotherapy分类
医药卫生引用本文复制引用
邓越,赵越,张石川..大分割放疗联合免疫治疗在头颈部鳞状细胞癌中的研究进展[J].中国癌症防治杂志,2025,17(2):244-250,7.基金项目
四川省科技计划项目(2022YFSY0055) （2022YFSY0055）
