中国医药科学2025，Vol.15Issue(8)：4-8,21,6.DOI:10.20116/j.issn2095-0616.2025.08.01
褪黑素通过抑制铁死亡改善环磷酰胺和白消安诱导的早发性卵巢功能不全小鼠的研究
Research on melatonin improving cyclophosphamide and busulfan-induced premature ovarian insufficiency in mice by inhibiting ferroptosis
摘要
Abstract
Objective To investigate the protective effect and mechanism of melatonin on cyclophosphamide and busulfan-induced premature ovarian insufficiency(POI)in mice by inhibiting ferroptosis pathway.Methods 6-week-old CD1 female mice were randomly divided into the control group,the POI group,and the POI+melatonin group.After establishing the POI model,mouse body weight,ovarian wet weight,serum hormone levels,follicle count,and ferroptosis related indices were detected.Results The weight,follicle count,and hormone levels of the POI group mice were significantly lower than those of the control group(P＜0.05),and the ferroptosis markers malondialdehyde,nuclear transcription factor E2 related factor,recombinant solute carrier family 7,member 11,and glutathione peroxidase 4 all increased(P＜0.01).After melatonin intervention,the body weight,follicle count,and serum hormone levels of mice all significantly improved(P＜0.05),while the expression levels of ferroptosis related markers malondialdehyde,glutathione,and nuclear transcription factor E2 related factor were significantly reduced(P＜0.01).Conclusion Melatonin improves POI by inhibiting the ferroptosis pathway and has potential clinical application value.关键词
早发性卵巢功能不全/铁死亡/褪黑素/环磷酰胺/白消安Key words
Premature ovarian insufficiency/Ferroptosis/Melatonin/Cyclophosphamide/Busulfan分类
临床医学引用本文复制引用
裴娇娇,腊晓琳..褪黑素通过抑制铁死亡改善环磷酰胺和白消安诱导的早发性卵巢功能不全小鼠的研究[J].中国医药科学,2025,15(8):4-8,21,6.基金项目
国家自然科学基金(81960289) （81960289）
四川省成都市卫生健康委员会科研项目(2022657). （2022657）
