中国肿瘤生物治疗杂志2025，Vol.32Issue(4)：418-424,7.DOI:10.3872/j.issn.1007-385x.2025.04.011
放疗作为原位疫苗的联合治疗模式在晚期软组织肉瘤中的应用
Exploration of radiotherapy as a combined treatment modality with in situ vaccines in the treatment of advanced soft tissue sarcomas
摘要
Abstract
Objective:To evaluate the efficacy and safety of radiotherapy as a combined mode with in-situ vaccine for patients with advanced soft tissue sarcoma(STS).Methods:The clinical data of 12 patients with advanced STS who received combination therapy mode at the Cancer Center of Gulou Hospital Affiliated to the School of Medicine of Nanjing University between December 2020 and September 2024 were retrospectively analyzed.All 12 patients received combined therapy.The main radiotherapeutic approach was hypofractionated radiotherapy.The targeted therapy mainly involved Anlotinib(in 10 cases)or Apatinib(in 2 cases).Immunotherapy mainly involved PD-1 antibodies.The primary endpoint was disease control rate(DCR),and the secondary endpoints were objective response rate(ORR)and safety.Results:Among the 12 STS patients who received combined treatment,0 cases achieved CR,4 cases achieved PR;7 cases had SD,and 1 case had PD.The ORR was 33%,and the DCR was 91.7%,among which the DCR of the target lesions was 100%.Among the 12 patients,9 patients experienced grade Ⅰ to grade Ⅱ adverse reactions.The most frequently occurring hematological adverse reactions were anemia(6 cases)and abnormal results of liver function tests(3 cases).The most frequently occurring non-hematological adverse reactions were proteinuria(5 cases),hypertension(4 cases),abnormal thyroid function(3 cases),anorexia(3 cases),and nausea and vomiting(2 cases).Only 2 cases had grade Ⅲ hematological toxicity,and 1 case had grade Ⅲpneumothorax.Conclusion:Radiotherapy as a combined therapy mode with in situ vaccine can achieve a higher DCR in advanced soft tissue sarcomas without serious adverse reactions.This combined treatment modality demonstrates good efficacy and safety.关键词
放疗/原位疫苗/免疫治疗/靶向治疗Key words
radiotherapy/in situ vaccine/immunotherapy/targeted therapy分类
医药卫生引用本文复制引用
谭思怡,刘宝瑞,李茹恬,王晓露,王琴,杜诗尧,尹方韬,杨艺琦,孙武,刘娟,周霞..放疗作为原位疫苗的联合治疗模式在晚期软组织肉瘤中的应用[J].中国肿瘤生物治疗杂志,2025,32(4):418-424,7.基金项目
国家自然科学基金(No.82272852) （No.82272852）
江苏省杰出青年学者基金(No.BK20240017) （No.BK20240017）
南京鼓楼医院临床研究专项资金培育项目(No.2022-LCYJ-PY-21) （No.2022-LCYJ-PY-21）
南京鼓楼医院临床研究专项资金(No.2022-LCYJ-MS-09) （No.2022-LCYJ-MS-09）
