中国中西医结合影像学杂志2025，Vol.23Issue(3)：273-278,6.DOI:10.3969/j.issn.1672-0512.2025.03.002
代谢相关脂肪性肝病全肝脂肪测定:LAVA-Flex和IDEAL-IQ技术测定全肝脂肪分数与PDFF一致性研究
Consistency research of PDFF and whole liver fat fraction measured by LAVA-Flex and IDEAL-IQ techniques in metabolic dysfunction-associated fatty liver disease
摘要
Abstract
Objective:Taking the whole-liver proton density fat fraction(PDFF)measured by MRI as the standard,to analyze the consistency between PDFF and the liver fat fraction(FF)in water-phase and fat-phase maps measured by MRI LAVA-Flex and IDEAL-IQ techniques in patients with metabolic dysfunction-associated fatty liver disease(MAFLD).To explore the feasibility of the LAVA-Flex technique for rapid detection of whole-liver fat quantification.Methods:97 patients with MAFLD and 23 healthy volunteers were enrolled.IDEAL-IQ sequence scan was performed to obtain the PDFF,R2*,water-phase,fat-phase,in-phase and opposed-phase maps,and LAVA-Flex sequence scan was performed to obtain the water-phase,fat-phase,in-phase and opposed-phase maps.3D Slicer software was used to outline the whole liver in the PDFF,water-phase and fat-phase maps,and the fat signal fractions(FFIQ and FFFlex)of the whole liver in the respective water-phase and fat-phase maps were calculated.According to the PDFF,120 cases were divided into 4 groups,the normal group(23 cases,PDFF<5%),the mild group(15 cases,5%≤PDFF<10%),the moderate group(48 cases,10%≤PDFF<25%)and the severe group(34 cases,PDFF≥25%).Correlation analysis was used to compare the consistency between FFIQ,FFFlex and PDFF in 4 groups,and correlation heat maps and Bland-Altman plots were drawn.Results:There was a significant correlation between the total FFFlex and PDFF(r=0.959).In the normal group,there was a significant correlation between FFIQ and PDFF(r=0.991,P<0.01).In the mild group,there was a relatively strong and significant correlation between FFIQ and PDFF(r=0.848,P<0.01).In the moderate group,the correlation between FFIQ and PDFF was extremely strong and significant(r=0.997,P<0.01),and the correlation between FFFlex and PDFF was relatively strong and signifi-cant(r=0.756,P<0.01).In the severe group,both FFIQ and FFFlex correlated significantly with PDFF(r=0.779,0.793,both P<0.01).The Bland-Altman plots showed that most of the data points of FFFlex and FFIQ fell within the limits of agreement,and the center line was close to 0,indicating their good consistencies with PDFF.Conclusions:Both the IDEAL-IQ and LAVA-Flex techniques show a high degree of consistency with PDFF in measuring the whole-liver FF,especially in patients with moderate and severe fatty liver.The LAVA-Flex technique,with the advantage of rapid imaging,provides another powerful tool for the determination of liver fat content in clinical practice.关键词
代谢相关脂肪性肝病/可变容积加速肝脏采集/非对称回波最小二乘估算法迭代水脂分离序列/磁共振成像/肝脏脂肪分数引用本文复制引用
王盛甲,朱高旺,陈鑫,张晓玉,张玉峰..代谢相关脂肪性肝病全肝脂肪测定:LAVA-Flex和IDEAL-IQ技术测定全肝脂肪分数与PDFF一致性研究[J].中国中西医结合影像学杂志,2025,23(3):273-278,6.基金项目
宝山区2022年科委课题(2023-E-41). （2023-E-41）
