中国中西医结合影像学杂志2025，Vol.23Issue(3)：320-324,335,6.DOI:10.3969/j.issn.1672-0512.2025.03.010
耳甲电针治疗早中期帕金森病即刻脑效应的fMRI研究
An fMRI study of immediate effect of transcutaneous auricular vagus nerve stimulation in treatment of early to mid-stage Parkinson's disease
摘要
Abstract
Objective:To observe the immediate regulatory effect of electroacupuncture on the auricular nail,namely transcutaneous auricular vagus nerve stimulation(taVNS),on the resting-state fMRI brain functional activities in early to mid-stage Parkinson's disease patients.Methods:Seventeen patients with early to mid-stage Parkinson's disease who took regular medication were selected as the case group,and 17 healthy controls matched with gender,age and education years were selected as the control group.The case group was treated with taVNS for 30 minutes,and resting-state fMRI scans were performed before and after treatment.Only resting-state fMRI scan was performed in the control group.The differences of brain-wide amplitude of low-frequency fluctuations(ALFF),fractional ALFF(fALFF)and regional homogeneity(ReHo)between the two groups were observed and compared,as well as the changes before and after taVNS.Results:Compared with the control group,the cerebella ALFF values,the fALFF values in the right cuneiform lobe/right talar sulcus,left precentral gyrus/left postcentral gyrus,and ReHo values in the right cerebellum,right rectangular sulcus/right cuneiform lobe/right lingual gyrus in the case group were reduced.After immediate taVNS,the ALFF values of bilateral supplementary motor area(SMA)/bilateral superior frontal gyri/left anterior cingulate/left paracingulate gyrus were increased in the case group compared with before taVNS.The above differences were statistical(GRF correction,cluster P<0.05,threshold voxel P<0.005).Conclusions:Patients with early to mid-stage Parkinson's disease who take regular medication still have abnormal brain function in cerebella and sensory and motor cortical brain regions,and the immediate modulation effect of taVNS is mainly concentrated in bilateral SMA and prefrontal lobes,which may be the brain mechanism of taVNS in the adjuvant treatment of patients with early to mid-stage Parkinson's disease.关键词
针刺/耳/迷走神经电刺激/帕金森病/磁共振成像/辅助运动区Key words
Acupuncture/Ear/Vagus nerve stimulation/Parkinson's disease/Magnetic resonance imaging/Supplementary motor area引用本文复制引用
高山山,但小娟,陈彪,方继良,张磊,郭春蕾,陈庆燕,曹久冬,罗屹,马跃,周涌涛,杨戈..耳甲电针治疗早中期帕金森病即刻脑效应的fMRI研究[J].中国中西医结合影像学杂志,2025,23(3):320-324,335,6.基金项目
中国中医科学院广安门医院自主经费课题(81269) （81269）
中央高水平中医医院临床科研业务经费(HLCMHPP2023072). （HLCMHPP2023072）
