中国合理用药探索2025，Vol.22Issue(4)：59-64,6.DOI:10.3969/j.issn.2096-3327.2025.04.009
左氧氟沙星联合甲硝唑预防急性阑尾炎术后切口感染的效果及对患者血清炎症因子水平的影响
Levofloxacin Combined with Metronidazole for Prevention of Postoperative Incision Infection in Patients with Acute Appendicitis and Its Effect on Patients'Serum Inflammatory Factor Levels
苗修会 1刘杰 2刘彦中1
作者信息
- 1. 河南省荣军医院急诊科,新乡 453000
- 2. 河南省荣军医院普外科,新乡 453000
- 折叠
摘要
Abstract
Objective:To analyze the efficacy of levofloxacin combined with metronidazole for prevention and treatment of postoperative incision infection in patients with acute appendicitis,and to study the levels of serum inflammatory factors such as interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and the influencing factors that lead to infection.Methods:A total of 102 patients with acute appendicitis who underwent surgical treatment in a hospital from May 2021 to May 2024 were selected and assigned to the observation group and control group by random number table,with 51 patients in each group.The control group was given metronidazole alone to prevent postoperative incision infection,while the observation group was given levofloxacin in addition to the treatment given in the control group.The incidence of postoperative infection and the levels of serum inflammatory factors before and after treatment were observed in the two groups.According to the occurrence status of incision infection,the clinical data of patients were observed to analyze the related influencing factors leading to incision infection.Results:The levels of IL-8,TNF-α and CRP in the two groups were decreased after 3 days of treatment,with the observation group showing lower levels than the control group(P<0.05).The incidence of postoperative incision infection in the observation group(9.80%)was lower than that in the control group(27.45%,P<0.05).Logistic regression analysis showed that age,onset time and incision irrigation were the main influencing factors that lead to incision infection(P<0.05).Conclusion:Levofloxacin combined with metronidazole showed significant efficacy for prevention of postoperative incision infection in patients with acute appendicitis.The incidence of infection after treatment was significantly decreased,and the levels of inflammatory factors were significantly regulated.Age,onset time and incision irrigation were the main influencing factors leading to incision infection,which should be paid attention to in clinical practice.关键词
甲硝唑/左氧氟沙星/预防/急性阑尾炎/切口感染/炎症因子Key words
metronidazole/levofloxacin/prevention/acute appendicitis/incision infection/inflammatory factor分类
医药卫生引用本文复制引用
苗修会,刘杰,刘彦中..左氧氟沙星联合甲硝唑预防急性阑尾炎术后切口感染的效果及对患者血清炎症因子水平的影响[J].中国合理用药探索,2025,22(4):59-64,6.
