中国合理用药探索2025，Vol.22Issue(4)：91-97,7.DOI:10.3969/j.issn.2096-3327.2025.04.014
促性腺激素释放激素类似物联合米非司酮对子宫腺肌病患者性激素、子宫内膜容受性、趋化因子受体的影响
Effects of Gonadotropin-Releasing Hormone Analogues Combined with Mifepristone on Sex Hormones,Endometrial Receptivity and Chemokine Receptors in Patients with Adenomyosis
摘要
Abstract
Objective:To study the efficacy of gonadotropin-releasing hormone analogues(GnRH-α)combine with mifepristone on sex hormones,endometrial receptivity(ER)and chemokine receptors in patients with adenomyosis(AM).Methods:110 patients with AM who were treated in a hospital from June 2019 to June 2023 were selected as study subjects,and divided into an observation group and a control group using the random number table method,with 55 cases in each group.The control group was treated with mifepristone,and the observation group was treated with leuprolide acetate microspheres for injection in addition to the control treatment.The following parameters were observed for the two groups before and after treatment:serum levels of sex hormones,including luteinizing hormone(LH),estradiol(E2)and follicle stimulating hormone(FSH)in luteal phase,ER parameters including vascularization flow index(VFI),flow index(FI),vascularization index(VI);serum levels of chemokine receptors including chemokine receptor-4(CXCR-4)and chemokine receptor-7(CXCR-7).Clinical indicators including dysmenorrhea severity,menstrual volume,uterine volume,as well as the occurrence of adverse reactions were recorded.Results:After treatment,the dysmenorrhea severity,menstrual volume and uterine volume in the observation group were decreased than those in the control group.VFI,FI,VI and CXCR-7 were higher in the observation group than those in the control group(P<0.05).The serum levels of LH,E2,FSH and CXCR-4 were lower in the observation group those in the control group(P<0.05).The total effective rate in the observation group(96.36%)was higher than that in the control group(80.00%,P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:GnRH-α in the treatment of adenomyosis demonstrated with favorable efficacy and effectively improved the levels of sex hormones and chemokine receptors,enhanced ER,without increasing the risk of adverse reactions.关键词
促性腺激素释放激素类似物/子宫腺肌病/性激素/子宫内膜容受性/趋化因子受体Key words
gonadotropin-releasing hormone analogues/adenomyosis/sex hormone/endometrial receptivity/chemokine receptor分类
医药卫生引用本文复制引用
李春蕾,郭玉生,郭凤枝..促性腺激素释放激素类似物联合米非司酮对子宫腺肌病患者性激素、子宫内膜容受性、趋化因子受体的影响[J].中国合理用药探索,2025,22(4):91-97,7.基金项目
河南省医学科技攻关计划项目(LHGJ20190089) （LHGJ20190089）
