中华临床免疫和变态反应杂志2025，Vol.19Issue(2)：81-88,8.DOI:10.3969/j.issn.2024-0090.2025.02.001
免疫细胞与系统性红斑狼疮因果关系的两样本双向孟德尔随机化分析
Bidirectional two-sample Mendelian randomization analysis of the causal relationship be-tween immune cells and systemic lupus erythematosus
摘要
Abstract
Objective Systemic lupus erythematosus(SLE)is an autoimmune disease with an un-clear pathogenesis.This study aims to explore whether there is a causal relationship between immune cells and SLE.Methods Immune cells were used as the exposure factor,and SLE as the outcome event.Single nucleo-tide polymorphisms(SNPs)closely related to immune cells and SLE were used as genetic instrumental varia-bles.A two-sample Mendelian randomization analysis method was employed to analyze genome-wide association study(GWAS)data.The main analysis method was inverse variance weighting(IVW),and odds ratios(OR)with 95%confidence intervals(95%CI)were used to evaluate the causal relationship between im-mune cells and SLE.Results The IVW method showed a causal relationship between 32 immune cell traits and SLE.The MR Egger regression analysis indicated no genetic pleiotropy(P>0.05).Reverse Mendelian ran-domization analysis showed a significant causal relationship between SLE and increased levels of myeloid cells expressing CD11b but not expressing HLA-DR.Conclusion Various lymphocytes and myeloid cells signifi-cantly influence the risk of developing SLE.关键词
免疫细胞表型/系统性红斑狼疮/孟德尔随机化/因果关系/全基因组关联分析Key words
immune cell phenotypes/systemic lupus erythematosus/mendelian randomization/causal relationship/genome-wide association study引用本文复制引用
侯传东,张虹,高楚蒙,卢学春,耿杰,陈浩然,何田田,张辉,李泓毅,张昊军,张力中,赵鹏..免疫细胞与系统性红斑狼疮因果关系的两样本双向孟德尔随机化分析[J].中华临床免疫和变态反应杂志,2025,19(2):81-88,8.基金项目
军队后勤科研项目保健专项课题(23BJZ25) （23BJZ25）
国家老年疾病临床医学研究中心多中心RCT临床研究项目(NCRCG-PLAGH-20230010) （NCRCG-PLAGH-20230010）
