转化医学杂志2025，Vol.14Issue(2)：15-19,5.DOI:10.3639/i.issn.2095-3097.2025.02.004
血清Furin、3-NT对2型糖尿病合并缺血性卒中患者颈动脉斑块易损性的评估价值
Exploration of the Value of Serum Furin and 3-Nitrotyrosine(3-NT)in Assessing Carotid Plaque Vulnerability in Patients With Type 2 Diabetes Mellitus(T2DM)and Ischemic Stroke(IS)
摘要
Abstract
Objective To explore the value of serum Furin and 3-nitrotyrosine(3-NT)in assessing the vulnerability of carotid plaque in patients with type 2 diabetes mellitus(T2DM)and ischemic stroke(IS).Methods 152 T2DM patients with IS were enrolled.They were divided into stable plaque group(n=63)and vulnerable plaque group(n=89)according to the nature of carotid plaques.Enzyme-linked immunosorbent assay was used to detect the levels of serum Furin and 3-NT in the two groups.The predictive value of serum Furin and 3-NT on carotid plaque vulnerability in T2DM patients with IS was evaluated by ROC curve analysis.Logistic regression analysis was used to explore the influencing factors of carotid plaque vulnerability in T2DM patients with IS.Results The serum Furin and 3-NT levels in the vulnerable plaque group were higher than those in the stable plaque group(P＜0.05).The area under the curve(AUC)(95％CI)of serum Furin,3-NT,and their combined prediction of carotid plaque vulnerability in T2DM patients with IS were 0.757(0.705-0.809),0.862(0.850-0.914),and 0.903(0.852-0.955),respectively.Long T2DM duration(OR=2.143,95％CI:1.459-3.146),elevated LDL-C level(OR=2.330,95％CI:1.568-3.462),Furin ≥277.56 pg/mL(OR=2.732,95％CI:1.772-4.213),and 3-NT ≥80.37 ng/mL(OR=3.480,95％CI:2.170-5.581)were identified as risk factors for carotid plaque vulnerability in T2DM patients with IS(P＜0.05).Conclusion Serum Furin and 3-NT exhibit predictive value for carotid plaque vulnerability in T2DM patients with IS,with their combined predictive value being higher.关键词
弗林蛋白酶/3-硝基酪氨酸/2型糖尿病/缺血性卒中/颈动脉斑块易损性Key words
Furin/3-nitrotyrosine/Type 2 diabetes mellitus/Ischemic stroke/Carotid plaque vulnerability分类
医药卫生引用本文复制引用
陈召东,赵超,刘燕妮,谢瑞涛,李黎黎,郭凡,李娜..血清Furin、3-NT对2型糖尿病合并缺血性卒中患者颈动脉斑块易损性的评估价值[J].转化医学杂志,2025,14(2):15-19,5.基金项目
陕西省重点计划项目(2019JM7512) （2019JM7512）
