中医学报（英文）2025，Vol.5Issue(1)：23-29,7.DOI:10.1055/s-0045-1807255
葛根素在防治阿尔茨海默病中作用研究进展
Research Progress on the Role of Puerarin in the Prevention and Treatment of Alzheimer's Disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disease that affects cognitive abilities in the elderly.Puerarin plays an important role in the prevention and treatment of AD.It exerts potential therapeutic effects in multiple aspects,including regulating the expression of amyloid β-protein(Aβ),inhibiting abnormal phosphorylation of microtu-bule-associated protein-T(Tau),scavenging free radicals,resisting oxidation,regulating metal metabolism to maintain cholinergic system stability,improving mitochondrial dysfunction,and resisting inflammation.However,the specific mechanisms by which puerarin protects cortical neurons in the brain are not fully explored.Hypothetical therapeutic pathways still require further scientific verification.关键词
阿尔茨海默病/葛根素/痴呆/大脑皮层神经元Key words
alzheimer's disease/puerarin/dementia/cortical neurons引用本文复制引用
褚长松,贾亚泉,刘源,杜若飞,王自闯,张振强,郑万春,宋军营..葛根素在防治阿尔茨海默病中作用研究进展[J].中医学报（英文）,2025,5(1):23-29,7.基金项目
This work was supported by the National Natural Science Foundation of China(82274612),Key Research Project of the Henan Academy of Chinese Medical Sciences(2024Y1031),Henan Province Key Research and Develop-ment and Promotion Special Project(Science and Tech-nology Research)(232102310505),Henan Province University Science and Technology Innovation Talents Program(23HASTIT044),and Henan University of Chinese Medicine Scientific Research Seedling Project(MP2023-08,MP2023-22). （82274612）
