中医药学报2025，Vol.53Issue(5)：58-62,5.DOI:10.19664/j.cnki.1002-2392.250097
痛风方联合非甾体抗炎药治疗急性痛风性关节炎对患者炎性指标、血液流变学的影响
Effects of Gout Formula Combined with Nonsteroidal Anti-inflammatory Drugs on Inflammatory Markers and Hemorheology in Patients with Acute Gouty Arthritis
摘要
Abstract
Objective:To analyze the efficacy of Gout Formula combined with nonsteroidal anti-inflammatory drugs(NSAIDs)in treating acute gouty arthritis.Methods:A total of 122 patients with acute gouty arthritis treated at Beijing Gulou Hospital of Traditional Chinese Medicine from October 2021 to December 2023 were included.Among them,61 patients treated with NSAIDs(diclofenac sodium)were assigned to the control group,while 61 patients treated with NSAIDs plus Gout Formula were assigned to the Gout Formula group.Clinical data of the two groups were retrospectively analyzed to compare serum uric acid levels,pain intensity,hemorheological parameters,inflammatory factor levels,and clinical efficacy before and after treatment.Adverse reactions such as allergic reactions,gastrointestinal discomfort,and abnormal liver or kidney function during treatment were recorded.Results:After treatment,the Gout Formula group showed significantly lower serum uric acid levels and visual analog scale(VAS)pain scores than the control group(P<0.01).Whole blood viscosity,plasma viscosity,and erythrocyte sedimentation rate in the Gout Formula group were significantly lower than those in the control group after treatment(P<0.05,P<0.01).Serum interleukin-1β and interleukin-8 levels in the Gout Formula group were significantly lower than those in the control group after treatment(P<0.01).The total effective rate was significantly higher in the Gout Formula group than in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Gout Formula combined with NSAIDs can reduce serum uric acid levels,alleviate pain,improve hemorheology,and suppress inflammatory responses in patients with acute gouty arthritis.The combined treatment enhances efficacy without increasing toxicity and demonstrates high safety.关键词
急性痛风性关节炎/痛风方/非甾体抗炎药/血液流变学/炎性因子/血尿酸Key words
Acute gouty arthritis/Gout Formula/Nonsteroidal anti-inflammatory drugs/Hemorheology/Inflammatory factors/Serum uric acid分类
中医学引用本文复制引用
张晶,顾雄华,李亚静,王巍..痛风方联合非甾体抗炎药治疗急性痛风性关节炎对患者炎性指标、血液流变学的影响[J].中医药学报,2025,53(5):58-62,5.基金项目
国家重点研发计划资助项目(2022YFC351201) （2022YFC351201）
北京中医药科技发展资金项目(QN2018-15) （QN2018-15）
第六批北京市级中医药专家学术经验继承工作项目(京中医科[2023]53号) （京中医科[2023]53号）
