中医药学报2025，Vol.53Issue(5)：79-83,5.DOI:10.19664/j.cnki.1002-2392.250101
通督解郁针法结合通窍解郁汤治疗脑卒中后抑郁的疗效及对神经递质的影响
Efficacy of Tongdu Jieyu Acupuncture Method Combined with Tongqiao Jieyu Decoction in Treating Post-Stroke Depression and Its Effects on Neurotransmitters
摘要
Abstract
Objective:To explore the efficacy of the Tongdu Jieyu acupuncture method combined with the Tongqiao Jieyu decoction in treating post-stroke depression and its effects on neurotransmitters.Methods:A total of 108 patients with post-stroke depression,admitted to the Department of Encephalopathy at Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine from January 2021 to December 2023,were randomly divided into a control group and an observation group,with 54 cases in each group.The control group received conventional Western medication,while the observation group was treated with the Tongdu Jieyu acupuncture method combined with the Tongqiao Jieyu decoction.Both groups were evaluated for changes in traditional Chinese medicine(TCM)syndrome scores,depression severity,and sleep quality before and after treatment.Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)test.Changes in dopamine(DA),norepinephrine(NE),and serotonin(5-HT)levels were compared between the two groups.Quality of life and treatment efficacy were also evaluated.Results:After treatment,both groups showed a significant decrease in TCM syndrome scores,HAMD scores,and PSQI index(P<0.05),with the observation group showing more significant improvement(P<0.05).The RBANS scores increased in both groups(P<0.05),and the observation group had higher scores than the control group(P<0.05).Both groups showed increased levels of DA,NE,and 5-HT after treatment(P<0.05),with the observation group showing more pronounced changes(P<0.05).The observation group had a higher treatment efficacy rate and better quality of life compared to the control group(P<0.01).Conclusion:The Tongdu Jieyu acupuncture method combined with the Tongqiao Jieyu decoction can alleviate depression,improve sleep quality and cognitive function,regulate serum neurotransmitter levels,and enhance the quality of life in patients with post-stroke depression.关键词
卒中后抑郁/通督解郁针/通窍解郁汤/神经递质/认知功能Key words
Post-stroke depression/Tongdu Jieyu acupuncture/Tongqiao Jieyu decoction/Neurotransmitters/Cognitive function分类
中医学引用本文复制引用
刘晶晶,张小健,郝春波,刘宏伟,焦雪蕾,周媛..通督解郁针法结合通窍解郁汤治疗脑卒中后抑郁的疗效及对神经递质的影响[J].中医药学报,2025,53(5):79-83,5.基金项目
北京市属医院科研培育计划项目(PZ2022015) （PZ2022015）
第六批北京市级中医药专家学术经验继承项目 （）
