中医药学报2025，Vol.53Issue(5)：107-113,7.DOI:10.19664/j.cnki.1002-2392.250106
中医药治疗胃低级别上皮内瘤变相关信号通路的研究进展
Research Progress on Traditional Chinese Medicine in Treating Low-Grade Intraepithelial Neoplasia of the Stomach and Its Associated Signaling Pathways
摘要
Abstract
Low-grade intraepithelial neoplasia(LGIN)of the stomach is a clinical chronic and common disease,characterized by glandular atrophy and thickening of the mucosal muscle layer,with accompanying mild to moderate atypical hyperplasia.As the degree of atypical hyperplasia increases,the risk of malignant transformation also rises.Therefore,LGIN has gained widespread attention as a key target for research and treatment.Modern medical treatments focus on symptom relief,but they are often ineffective for patients with chronic conditions and are associated with side effects such as diarrhea and constipation.Traditional Chinese Medicine(TCM)offers unique advantages in treating this condition,utilizing methods such as herbal decoctions,acupuncture,and topical applications to regulate various signaling pathways.While current domestic studies primarily focus on the clinical efficacy of TCM in treating LGIN,there is a lack of comprehensive documentation on how TCM regulates the various signaling pathways involved in the pathogenesis of LGIN.This review aims to summarize the relationships between the SHH,NF-κB,PI3K/Akt,MAPK,Hippo,and JAK/STAT signaling pathways and LGIN,and discusses the current status of TCM treatment for this condition.By elucidating the specific mechanisms,this review provides new perspectives and theoretical support for the treatment of LGIN.关键词
低级别上皮内瘤变/信号通路/研究进展Key words
Low-grade intraepithelial neoplasia(LGIN)/Signaling pathways/Research progress分类
医药卫生引用本文复制引用
周羚,梁国英..中医药治疗胃低级别上皮内瘤变相关信号通路的研究进展[J].中医药学报,2025,53(5):107-113,7.基金项目
黑龙江省自然科学基金联合引导项目(LH2022H072) （LH2022H072）
全国中医临床特色技术传承骨干人才培训项目(国中医药人教函[2019]36号) （国中医药人教函[2019]36号）
黑龙江省博士后基金(LBH-Z12266) （LBH-Z12266）
黑龙江省博士后科研启动项目(LBH-Q17169) （LBH-Q17169）
